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[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...
Torres, N.; Gonçalves, S.; Fernandes, A. S.; Machado, J. F.; de Brito, M. J.; Oliveira, N. G.; Castro, M.; Costa, J.; Cabral, M. F.The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...
Development of pyridine-containing macrocyclic copper(II) complexes: potential ...
Fernandes, A. S.; Costa, J.; Gaspar, J.; Rueff, J.; Cabral, M. F.; Cipriano, M.; Castro, M.; Oliveira, N. G.The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...
Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...
Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...
Estudo do comportamento eletroquímico do herbicida ametrina utilizando a técnic...
Cabral,M. F.; Souza,D. de; Alves,C. R.; Machado,S. A. S.Foi realizado um estudo do comportamento eletroquímico do herbicida ametrina em meio ácido utilizando a técnica de voltametria de onda quadrada (SWV) combinada com eletrodo de gota suspensa de mercúrio (HMDE). O processo de redução da ametrina envolve a protonação prévia da molécula, seguido da transferência irreversível de dois elétrons com controle de velocidade dado pelo transporte de massa. A corrente de pi...
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