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[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...

The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...

Histological evaluation of the spleen after acute bleeding followed by volume r...

Spleen is important for many hematopoietic and immunological functions, namely in hemodynamic compensation during hemorrhagic shock, with a crucial role in restoring blood volume in situations of acute haemorrhage. Also, the administration of physiological solutions is of great importance for the correction of circulating volume, avoiding complications due to hypovolemia. The aim of this study was to eval...

Determinação de Trihalometanos em piscinas do Concelho de Lisboa. Classificação...

Fulminant Myocarditis Associated with Pandemic H1N1 Influenza A Virus

Fulminant myocarditis associated with influenza A virus is exceedingly rare, with only a few cases reported in the literature. We describe a previously healthy 10-year-old boy, with a three-day history of flu-like symptoms without antiviral treatment. He was hospitalized with dehydration and hypothermia in the context of persistent vomiting, when he suddenly developed heart failure secondary to fulminant myocar...

Development of pyridine-containing macrocyclic copper(II) complexes: potential ...

The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...

Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...

Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...

Factores de risco cardiovascular e obesidade infantil

Introdução: a obesidade associa-se, mesmo em idade pediátrica, a factores de risco de doença cardiovascular, como a dislipidemia, a tensão arterial (TA) elevada e o síndrome metabólico (SM), que contribuem para o aumento da morbilidade e mortalidade na idade adulta. Objectivos: caracterizar a prevalência dos factores de risco cardiovascular nas crianças e adolescentes obesos seguidos na consulta de Endocrinolog...

kawasaki disease in a young infant: diagnostic challenges

Kawasaki disease (KD) is a multisystem vasculitis condition with a relatively unknown etiology. It has a high prevalence in children ages 6 months to 5 years, and patients often present with high fever, rash, cervical lymphadenopathy and mucocutaneous abnormalities. Visceral manifestations can be present, being coronary complications the most frequent. There is no diagnostic test for KD, its presentation can be...

Proctated febril myalgia syndrome com purpura de Henoch-Schonlein: forma atipic...

A Febre Mediterrânica Familiar (FMF) é uma doença hereditária autossómica recessiva caracterizada por episódios de febre recorrente, artrite e poliserosite – peritonite, pleurite e/ou pericardite. A sua principal complicação é a amiloidose AA sistémica. Menina de 8 anos, origem africana, com febre recorrente desde os 5 anos e três internamentos com febre, dor abdominal e elevação dos reagentes de fase aguda. No...

Catastrophic antiphospholipid syndrome: first signs in the neonatal period

The term "catastrophic" antiphospholipid syndrome (CAPS) is used to define a subset of the antiphospholipid syndrome (APS) characterized by the clinical evidence of three or more organ involvement by thrombotic events in a short period of time and with laboratory confirmation of the presence of antiphospholipid antibodies. We describe a male infant first admitted at 17 days old for necrotizing enteritis complic...