One of the most common characteristics of the Portuguese littoral is the existence of a planed surface (the so-called "littoral platform"), situated at different altitudes and bordered from the inland by a straight relief, strongly contrasting with that planed surface. This one is generally covered with several outcrops of the so-called Plio-Pleistocene deposits. Till the eighties this platform has been interpr...
This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the biological response of myoblast cells. Non-poled, ‘‘poled +’’ and “poled-“ -PVDF were prepared in the form of films. Further, random and aligned electrospun -PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation an...
The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the process of product development. In this work, the biodistribution of recently developed self-assembled dextrin nanopar...
Prion-like Doppel gene (PRND) is located downstream from priori protein gene (PRNP). Doppel protein is not related to prion disease but to male fertility. Our previous analysis of PRND coding region in 460 animals from 8 Portuguese sheep breeds, by multiple restriction fragment-single strand conformation polymorphism (MRFSSCP), revealed a synonymous substitution (78G>A). An association was found between identif...
We propose a new method to measure changes in terrain topography from two optical stereo image pairs acquired at different dates. The main novelty is in the ability of computing the spatial distribution of uncertainty, thanks to stochastic modeling and probabilistic inference. Thus, scientists will have access to quantitative error estimates of local surface variation, so they can check the statistical signific...
This work aims at presenting a stratigraphic and morphotectonic regional framework of the quartzite relief of the Soutelo - Arrancada do Vouga - Águeda structural domain (Iberian Massif, NW Portugal). The Armorican quartzite discontinuous outcrops take the form of a narrow N-S strip, with a 1 km wide, of Lower Palaeozoic age, which is included in a major crustal-scale strike-slip zone, the so-called Porto-Coimb...
This work emphasizes the importance of recovery processes of abandoned mining heritage, as an example of the transformative process of an organization towards a second life cycle. This perspective reflects an important measure for sustainability, either for the organization and the surrounding environment. The Aveleira Mine is an old wolfram mine, belonging to the Monastery of St Martin of Tibães, near Braga, i...
The porcine stress syndrome or malignant hyperthermia is an inherited autosomic recessive disease, which results in neuromuscular disorders leading to death in homozygous individuals and is associated with deterioration of meat quality. The defect in susceptible animals results from modifications in the calcium release channel or Ryanodine Receptor (RYR1), with a mutation leading to a C to T transition in nucle...
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