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Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to...
Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J.Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitoch...
Complex Formation between Heptakis(2,6-di-O-methyl)-β-cyclodextrin and Cyclopen...
Pereira, Cláudia C. L.; Diogo, Cátia V.; Burgeiro, Ana; Oliveira, Paulo J.; Marques, Maria Paula M.; Braga, Susana S.; Paz, Filipe A. AlmeidaThe inclusion compounds isolated from nonaqueous solutions of heptakis(2,6-di-O-methyl)-β-cyclodextrin (DIMEB) and the complexes [CpMoL2(CO)2](BF4) (L = MeCN, L2 = 2,2′-biimidazole) were characterized in the solid state by powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), 13C1H CP/MAS NMR, and FTIR spectroscopy. Powder XRD showed that the compound with [CpMo(MeCN)2(CO)2](BF4) was amorphous, whil...
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