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Genetic screening of Alzheimer's disease genes in Iberian and African samples y...
Guerreiro, RJ; Baquero, M; Blesa, R; Boada, M; Bras, JM; Bullido, MJ; Calado, A; Crook, R; Ferreira, C; Frank, A; Machado, A; Oliveira, CR; Santana, IMutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65 years) Alzheimer's disease (AD). We performed a screening for mutations in the coding regions of presenilins, as well as exons 16 and 17 of the APP gene in a total of 231 patients from the Iberian peninsular with a clinical diagnosis of early-onset AD (mean age at onset of 52.9 years; range 31-64). We found t...
Transumbilical Single-Incision Laparoscopic Surgery: A single center experience
Kirshniak, Andreas; Department of General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, GermanyDuring the last two years, the so called Single-incision-laparoscopic surgery is developing rapidly and seems to be the next step in reducing abdominal wall trauma for laparoscopic abdominal procedures. Different techniques and equipment are under development and reports cumulate regarding laparoscopic procedures which are performed through one single skin incision. We report our first experiences in single inc...
Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding ...
Pato, Carlos N.; Middleton, Frank A.; Gentile, Karen L.; Morley, Christopher P.; Medeiros, Helena; Macedo, Antonio; Azevedo, M. Helena; Pato, Michele T.We recently reported genome-wide significant linkage to chromosome 6q for bipolar disorder, in a study of 25 Portuguese families, using the Human Mapping Assay Xba 131 (HMA10K). To explore the generalizability of this finding, we reanalyzed our SNP linkage data according to the families' geographic origin. Specifically, the 25 families included 20 families from the Portuguese island collection (PIC; 15 families...
Gene expression analysis of peripheral blood leukocytes from discordant sib-pai...
Middleton, Frank A.; Pato, Carlos N.; Gentile, Karen L.; McGann, Lindsay; Brown, Andrea M.; Trauzzi, Marco; Diab, Heba; Morley, Christopher P.We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib-pairs that were discordant for either schizophrenia (n = 33 sib-pairs) or bipolar disorder (n = 5 sib-pairs). The pairs chosen for these analyses were selected from families with known patterns of genetic linkage (5q for schizophrenia and 6q for bipolar disorde...
Spectroscopic Study of the Hydration Equilibria and Water Exchange Dynamics of ...
Yerly, Fabrice; Dunand, Frank A.; Tóth, Éva; Figueirinha, Artur; Kovács, Zoltán; Sherry, A. Dean; Geraldes, Carlos F. G. C.; Merbach, André E.The hydration state of a series of [Ln(DO2A)(H2O)n]+ complexes in aqueous solution at pH = 6.4-7.0 was studied by measuring the lanthanide-induced 17O shifts (LIS) of water [Ln includes elements from Ce to Yb; DO2A = 1,7-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane]. Their contact contribution, obtained from Reilley plots, indicated a decrease in the inner-sphere water coordination number of the [Ln(DO2A)(...
Growth enhancement ofbBifidobacterium lactis Bo and Lactobacillus acidophilus K...
Gomes, Ana M.P.; Malcata, F. Xavier; Klaver, Frank A.M.The determination of the best conditions of preparation of a (tentatively) probiotic starter culture that might be suitable for cheese making composed solely of Bifidobacterium lactis Bo and Lactobacillus acidophilus Ki is critical if a consistently reliable acid production is to be achieved, especially because bifidobacteria have stringent requirements for growth. Therefore, we determined whether B. lactis Bo ...
Potencial alelopático de 2-benzoxazolinona (boa) e sua interação com atrazine n...
Souza,Itamar F.; Einhellig,Frank A.Dois experimentos de laboratório foram conduzidos na Universidade de South Dakota, Vemillion, SD, EUA, em 1990, para determinar os efeitos do ácido hidroxâmico benzoxazolinona (BOA), do herbicida atrazine e de suas misturas sobre o crescimento e teor de clorofila de lentilha dágua (Lemna minor). BOA na concentração de 0,5 mM foi aplicado em combinação com atrazine a 0,001 e 0,005 mM em caixas plásticas com 24 c...
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