The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy to enhance the first step of neurogenesis, proliferation of neural stem cells (NSC). In this work, we have studied...
In this study we evaluated the neurotoxicity of eslicarbazepine acetate (ESL), and of its in vivo metabolites eslicarbazepine (S-Lic) and R-licarbazepine (R-Lic), as compared to the structurally-related compounds carbamazepine (CBZ) and oxcarbazepine (OXC), in an in vitro model of cultured rat hippocampal neurons. The non-related antiepileptic drugs (AEDs) lamotrigine (LTG) and sodium valproate (VPA) were also ...
Physical function is limited post-liver transplantation and exercise training can improve exercise capacity following transplantation but previously assessment of functional capacity is necessary. The 6 minute walk test (6MWT) is routinely used for studying patient’s exercise capacity and is less expensive and time consuming than a Cardiopulmonary Exercise Test (CPXT). There have been some studies looking at th...
2011– Abstract publication “Reliability of the Six Minute Walk Test and Timed Up & Go Test in Persons with Transfemoral Amputation”, Physiotherapy, 97, Supplement 1, June 2011, p: S18-S1415 - Special Interest Report Abstracts, pages. S227. (IF=0.641) ; Purpose: The purpose of this study was to analyze the between two days test-retest reliability of the Six-Minute Walk Test (6MWT) in persons with Transfemoral (...
O presente estudo pretende comparar a distribuição vertical da comunidade bêntica na zona entremarés em dois locais compostos por matacões graníticos caracterizados por hidrodinâmica distinta, reflexo da diferença na orientação dos molhes nas praias do Farol de São Tomé (Píer) e na Barra do Furado (Barra), norte do Estado do Rio de Janeiro. Quadrados de 400 cm² foram sobrepostos ao longo de três perfis verticai...
Two eimerid coccidia are reported in a capybara (Hydrochoerus hydrochaeris) population kept in captivity in the south of Bahia, northeastern Brazil (14º 47' 57.89"S and 39º 10' 10.58" W). Oocysts of Eimeria ichiloensis are subspheroidal to ellipsoidal, 26.2 x 21.7mm with bi-layered wall, the outer yellow and sculptured and the inner, dark and smooth. Residuum is absent, but usually 2-3 polar granules are presen...
Com o intuito de elucidar a relação entre transtornos do controle de impulsos (TCI) e transtorno obsessivo-compulsivo (TOC), faz-se mister estudar subgrupos mais clinicamente homogêneos de transtornos impulsivos. Por meio do relato de quatro casos de pacientes com TOC e diferentes tipos de transtornos parafílicos (fetichismo transvético, sadismo, ginandromorfofilia e exibicionismo), são discutidos os conceitos ...
BACKGROUND: U-shaped sacral fractures are highly unstable, can cause significant neurological deficits, lead to progressive deformity and chronic pain if not treated appropriately. OBJECTIVE: To report a case of a U-shaped sacral fracture treated with lumbopelvic fixation and decompression of sacral roots in a 23-years-old man. METHOD: Decompression of the sacral roots combined with internal reduction and lumbo...
OBJECTIVE: To describe our experience with C1 lateral mass screws as part of a construct for C1-2 stabilization and report an alternate method of C1-C2 complex three-point fixation. METHOD: All patients that had at least one screw placed in the lateral mass of C1 as part of a construct for stabilization of the C1-C2 complex entered this study. In selected patients who had a higher chance of nonunion an alternat...
Este artigo parte de uma discussão da concepção weberiana do mercado como a forma por excelência de "socialização entre estranhos" para refletir teoricamente sobre modernização e mercado. Para além das evidentes sugestões envolvidas na reflexão sobre o papel do mercado no mundo contemporâneo, procura-se estabelecer alguns nexos específicos não obstante todas as tensões envolvidas entre o arquétipo do mercad...
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