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Angiotensin II mediates catecholamine and neuropeptide Y secretion in human adr...
Cavadas, Cláudia; Grand, Daniela; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to study the effect of angiotensin II (Ang II) on catecholamines and neuropeptide Y (NPY) release in primary cultures of human adrenal chromaffin cells. Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. The NPY release is more sustained than that of catecholamines. We found that the recepto...
NPY regulates catecholamine secretion from human adrenal chromaffin cells
Cavadas, Cláudia; Silva, António P.; Mosimann, François; Cotrim, Maria Dulce; Ribeiro, Carlos Alberto Fontes; Brunner, Hans R.; Grouzmann, EricThe aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Accordingly, the constitutive and regulated release of both NPY and catecholamines was measured simultaneously in cultured human chromaffin cells. In addition, by using both RT-PCR and a combination of specific agonists and...
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