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[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...
Torres, N.; Gonçalves, S.; Fernandes, A. S.; Machado, J. F.; de Brito, M. J.; Oliveira, N. G.; Castro, M.; Costa, J.; Cabral, M. F.The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...
Outbreak of acute respiratory infection among infants in Lisbon, Portugal, caus...
Rebelo-de-Andrade, Helena; Pereia, C.; Giria, M.; Prudêncio, E.; Brito, M.J.; Calé, E.; Taveira, N.Human adenoviruses (AdVs) typically cause mild illnesses in otherwise healthy hosts. We investigated a pediatric outbreak of acute respiratory infection with fatal outcomes that occurred in Lisbon, Portugal, in 2004.Biological specimens were collected from 83 children attending two nurseries, a kinesiotherapy clinic, and the household of a nanny. Adenovirus infection was confirmed in 48 children by PCR and viru...
Infecções Respiratórias por Influenza: Reflexões para a ausência de um diagnóstico
Machado, R.; Brito, M. J.; Loureiro, V.; Ferreira, G.RESUMO Introdução: O vírus influenza afecta anualmente 10 a 40% das crianças e destas 0,5 a 1% vão necessitar de internamento. Ao averiguar a prevalência desta infecção no internamento do Hospital Dona Estefânia, entre Janeiro de 2004 e Junho de 2006, constatámos a existência de apenas nove casos diagnosticados. Objectivos: Determinar as causas da escassez do número de diagnósticos de infecções pelo vírus influ...
Nephrotic syndrome. What is new since the 1988 study?.
Seves, M G; Serviço 2, Unidade de Nefrologia, Hospital de Dona Estefânia, Lisboa.; Brito, M J; Lamy, S; Luiz, P V; Bastos, G; Faleiro, M; Batista, JThe authors make a retrospective review of 53 new cases of Nephrotic Syndrome followed up in the Nephrology Unit from November 1988 to March 1994, bearing in mind the evaluation of casual changes of the disease standard regarding a previous study of 1988. Epidemiological, clinical, therapeutical and evolutional aspects were studied. Forty-four cases of primary Nephrotic Syndrome (83%) were identified, 61.4% of ...
A resurgence of rheumatic fever. New causes or old attitudes?.
Brito, M J; Serviço Pediatria, Hospital de Da. Estefânia, Lisboa.; Afonso, I; Flores, H; Pinto, S; Macedo, A J; Trindade, L; Freitas, O; Almeida, TBearing in mind that in the last years there has been an increase in rheumatic fever episodes, the authors evaluate the cases recently observed in the department. The data of 3 children born and living in Portugal, the first known outbreak of rheumatic fever observed between June 93 and March 94, were examined. One case presented polyarthritis, another polyarthritis and carditis and the third chorea and carditi...
Structural changes in pulmonary vessels and coronary arteries in hypoplastic le...
Macedo, A; Serviços de Cardiologia Pediátrica e de Anatomia Patológica, Hospital de Santa Marta, Lisboa.; Pinto, E; Ramos, S; Brito, M J; Costa, M MIn order to correlate gross morphological features with pulmonary and coronary vasculature changes in hypoplastic left heart syndrome (HLHS) 15 heart-lung necropsy specimens from neonates were analysed. Histology of left atrium wall, lung vessels with pulmonary arteriolar disease morphometric grading, study of intra and extra pulmonary wall veins and coronary arteries were recorded. Classic HLHS was observed in...
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