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Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plas...
Mendes, J; Martinho, A; Simões, O; Mota, A; Breitenfeld, L; Pais, LImmunosuppressive drugs, such as tacrolimus (FK506) and cyclosporine (CsA), play an essential role in graft survival, preventing rejection. Large interindividual differences in drug-metabolizing enzymes as well as in drug transporters make the task of reaching the optimal concentrations difficult. The bioavailability of CsA and FK506 seems to be associated with the cytocrhome P450 IIIA (CYP3A) gene. It has also...
Data: 2009
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Origem: Repositório do Centro Hospitalar e Universitário de Coimbra
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