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Analysis of heart rate variability in a rat model of induced pulmonary hyperten...
Gonçalves, H; Henriques-Coelho, T; Bernardes, J; Rocha, AP; Brandão-Nogueira, A; Leite-Moreira, AMonocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine, wa...
Effect of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension
Henriques-Coelho, T; Brandão-Nogueira, A; Moreira-Gonçalves, D; Correia-Pinto, J; Leite-Moreira, AFINTRODUCTION: TNF-alpha blockade in ischemic heart failure is still the subject of debate since clinical trials show conflicting results. However, its benefit in heart failure secondary to pulmonary hypertension has yet to be determined. It has been reported that transgenic rats overexpressing TNF-alpha develop pulmonary hypertension. The aim of this study was to assess the morphologic and hemodynamic effects o...
Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating IL-6 ...
Henriques-Coelho, T; Oliveira, SM; Moura, RS; Roncon-Albuquerque R, Jr.; Neves, AL; Santos, M; Nogueira-Silva, C; La Fuente Carvalho, FThe pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflammatory cytokine gen...
Ghrelin reverses molecular, structural and hemodynamic alterations of the right...
Henriques-Coelho, T; Roncon-Albuquerque R, Jr.; Lourenço, AP; Baptista, MJ; Oliveira, SM; Brandão-Nogueira, A; Correia-Pinto, J; Leite-Moreira, AFGhrelin is an endogenous peptide that has a dual effect by activating specific receptors and by stimulating release of growth hormone. There is increasing evidence that ghrelin has a potent vasodilator effect. Recently, we demonstrated that exogenous administration of ghrelin modulates its endogenous levels and attenuates the majority of alterations induced by monocrotaline (MCT). In the present study, we evalu...
Acute changes of biventricular gene expression in volume and right ventricular ...
Roncon-Albuquerque R, Jr.; Vasconcelos, M; Lourenço, AP; Brandão-Nogueira, A; Teles, A; Henriques-Coelho, T; Leite-Moreira, AFOBJECTIVE: We investigated the effects of acute volume and RV pressure overload on biventricular function and gene expression of BNP, pro-inflammatory cytokines (IL-6 and TNF-alpha), iNOS, growth factors (IGF-1, ppET-1), ACE and Ca2+-handling proteins (SERCA2a, phospholamban and calsequestrin). METHODS: Male Wistar rats (n=45) instrumented with pressure tip micromanometers in right (RV) and left ventricular (LV...
Activation profile of pro-inflammatory cytokines in acute cardiac overload
Roncon-Albuquerque R, Jr.; Vasconcelos, M; Lourenço, AP; Brandão-Nogueira, A; Teles, A; Faria, B; Henriques-Coelho, T; Leite-Moreira, AFINTRODUCTION: Pro-inflammatory cytokines have been implicated in ventricular remodeling during heart failure progression. In the present study, we investigated the effects of acute volume and RV pressure overload on biventricular hemodynamics and myocardial gene expression of IL-6 and TNF-alpha. METHODS: Male Wistar rats (n = 45) instrumented with RV and LV tip micromanometers were randomly assigned to one of t...
Endogenous production of ghrelin and beneficial effects of its exogenous admini...
Henriques-Coelho, T; Correia-Pinto, J; Roncon-Albuquerque R, Jr.; Baptista, MJ; Lourenço, AP; Oliveira, SM; Brandão-Nogueira, A; Teles, A; Fortunato, JMWe investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Adult Wistar rats randomly received a subcutaneous injection of MCT (60 mg/kg) or an equal volume of vehicle. One week later, animals were randomly assigned to receive a subcutaneous injection of ghrelin (100 mug/k...
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