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Investigation of the in vivo genotoxic effects of a titanium dioxide nanomateri...

Titanium dioxide nanomaterials (TiO2) are increasingly used in a diversity of products, including cosmetics, pharmaceuticals, food and inks, which contrasts with the existing uncertainties in respect to their risks for human and environment health. Previous studies on the genotoxicity of TiO2 reported discrepant findings, both in cellular and organismal systems. In a recent work, we showed that some nanosized T...

Caracterização da genotoxicidade de nanomateriais manufaturados e potencial imp...

Os nanomateriais manufaturados (NMs), isto é, materiais fabricados que contêm partículas em que uma ou mais dimensões externas se situam na gama de tamanhos compreendidos entre 1 nanómetro e 100 nanómetros1 apresentam propriedades físico-químicas únicas (e.g., dimensão, área superficial, funcionalização) que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas muito vantajosas, relativamente a...

Nanomateriais manufaturados: novos desafios para a saúde

Os nanomateriais manufaturados (NM)apresentam propriedades físico-químicas específicas que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas únicas e vantajosas para aplicações industriais e biomédicas. Contudo, o desenvolvimento exponencial das nanotecnologias contrasta com a ainda insuficiente avaliação de risco para a saúde humana e para o ambiente, conduzindo a preocupações em termos de...

Nanotecnologias e saúde pública

Os nanomateriais manufaturados (NMs), isto é, fabricados deliberadamente para fins específicos, apresentam propriedades físico-químicas únicas (e.g., dimensão, área superficial, funcionalização) que lhes conferem caraterísticas mecânicas, óticas, elétricas e magnéticas muito vantajosas para aplicações industriais e biomédicas. Efetivamente depositam-se grandes expetativas nas tecnologias baseadas nestes NMs, as...

Nanomaterials safety investigation: analysis of genotoxic effects in a human br...

The human and environment exposure to manufactured nanomaterials (NMs) has been increasing worldwide. The specific properties of MNMs (as size and high surface area/mass) render them attractive for many applications, but may also be associated to higher toxicity in biological systems and adverse effects in humans. The objective of the present work was to evaluate the potential genotoxic effects of several well ...

Biomonitoring the genetic effects of environmental tobacco smoke exposure in re...

Environmental tobacco smoke (ETS) is recognized as one of the most common indoor pollutants worldwide. Portuguese legislation prohibits smoking in most indoor public spaces. However, in some restaurants/bars smoking is still allowed, representing a potential risk factor for the workers health, particularly for chronic respiratory diseases and cancer onset.The aim of this study was to characterize early signs of...

Safety evaluation of manufactured nanomaterials: comparison of genotoxic effect...

Nanotechnologies are developing very rapidly and presently, nanomaterials are increasingly used in a wide range of applications in science, industry and biomedicine. While a lot of effort has been put in the development of new manufactured nanomaterials (NMs) and in many innovative applications of nanothecnologies, comparatively less research has been performed to evaluate their safety for humans and the enviro...

In vitro testing strategy for nanomaterials including database (Deliverable 5):...

WP5 had two objectives: - To generate in vitro genotoxicity data on manufactured MNs (specific objective #3). - To perform a round robin test on in vitro genotoxicity testing of MNs (specific objective #4) WP5 addressed the basic questions of in vitro genotoxicity testing of manufactured nanomaterials (MNs): how well in vitro assays can be used for revealing the genotoxic potential of MNs, which assays are suit...

Estudos da toxicidade de misturas de aflatoxina M1 e ocratoxina A numa linha ce...

Formação de subprodutos de desinfeção da água e avaliação do seu potencial geno...