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Synergistic impact of endurance training and intermittent hypobaric hypoxia on ...

Magalhães, J.; Falcão-Pires, I.; Gonçalves, I. O.; Lumini-Oliveira, J.; Marques-Aleixo, I.; Passos, E. dos; Rocha-Rodrigues, S.; Machado, N. G.

Background Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function. Methods Two-sets of rats were divided into no...


Neuregulin attenuates right ventricular hypertrophy and dysfunction in an exper...

Maia-Rocha, C.; Adão, R.; Mendes-Ferreira, P.; Mendes, M.J.; Pinho, S.; Lourenço, A.P.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen

[abstract] ; [resumo]


Neuregulin attenuates pulmonary endothelial dysfunction in an experimental mode...

Adão, R.; Maia-Rocha, C.; Mendes-Ferreira, P.; Mendes, M.J.; Cerqueira, R.J.; Castro-Chaves , P.; De Keulenaer, G.W.; Leite-Moreira, A.F.

[abstract] ; [resumo]


A neuregulina-1 atenua a disfunção endotelial na hipertensão arterial pulmonar

Mendes-Ferreira, P.; Adão, R.; Cerqueira, R.J.; Maia-Rocha, C.; Mendes, M.J.; Castro-Chaves, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.

[abstract] ; [resumo]


A neuregulina atenua a hipertrofia e a disfunção ventricular direitas num model...

Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Lourenço, A.P.; Moura, C.; Mendes,M.J.; Pinho, S.; Areias, J.C.; De Keulenaer, G.W.; Leite-Moreira, A.F.

[abstract] ; [resumo]


Moderate exercise training provides left ventricular tolerance to acute pressur...

Moreira-Gonçalves, D; Henriques-Coelho, T; Fonseca, H; Ferreira, RM; Amado, F; Leite Moreira, A; Duarte, JA

The present study evaluated the impact of moderate exercise training on the cardiac tolerance to acute pressure overload. Male Wistar rats were randomly submitted to exercise training or sedentary lifestyle for 14 wk. At the end of this period, the animals were anaesthetized, mechanically ventilated, and submitted to hemodynamic evaluation with biventricular tip pressure manometers. Acute pressure overload was ...


Comparison of different methods of heart rate entropy analysis during acute ano...

Gonçalves, H; Henriques-Coelho, T; Rocha, AP; Lourenço, AP; Leite-Moreira, A; Bernardes, J

Acute life-threatening situations are particularly critical when superimposed on chronic diseases. The objective of this study was the assessment of heart rate (HR) dynamics during episodes of acute anoxia superimposed on a rat model of chronic pulmonary hypertension. In 10 adult Wistar rats, five weeks after pulmonary hypertension induction with Monocrotaline, we analysed eight 1-min HR segments, during episod...


Analysis of heart rate variability in a rat model of induced pulmonary hyperten...

Gonçalves, H; Henriques-Coelho, T; Bernardes, J; Rocha, AP; Brandão-Nogueira, A; Leite-Moreira, A

Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine, wa...


Linear and nonlinear heart-rate analysis in a rat model of acute anoxia

Gonçalves, H; Henriques-Coelho, T; Bernardes, J; Rocha, AP; Nogueira, A; Leite-Moreira, A

The objective of this study was the assessment of heart-rate (HR) dynamics with linear and nonlinear methods during episodes of mechanical ventilation and acute anoxia in rats. Namely, to assess whether linear and nonlinear HR analysis was able to discriminate acute anoxia from baseline in rats and if this was consistent with human foetal and adult studies. Five HR segments of 1 min duration, during baseline re...


Expressão medular renal do receptor tipo A dos peptídeos natriuréticos num mode...

Araújo C.; Roncon Albuquerque R.; Coelho T.; Teles R.; Rodrigues M.; Maia M.; Leite Moreira A.; Pestana M.


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia