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Vigilância laboratorial das infeções por Neisseria gonorrhoeae em Portugal, 200...

Chlamydia trachomatis infection in patients selected for HPV detection

Background: The significance of the association between the human papillomavirus (HPV) and other sexually transmitted infections in the development of cervical, penile or anal neoplasias has been investigated, and the more consistent data have pointed to an association with Chlamydia trachomatis. In Portugal, the lack of information on STI precludes any knowledge on this subject. Objective: To determine CT infe...

Transcriptomic analysis of plasmid and plasmid-related chromosomal ORFs in C. t...

Despite the undergoing chromosomal size-reduction of Chlamydia trachomatis, almost all strains maintain the conserved 7,5kb plasmid. It has been recently considered a virulence factor, as plasmid-bearing strains evidenced a higher ability to successfully colonize epithelial cells and sustain infection than plasmidless strains. However, the biological role of the eight plasmid ORFs remains poorly characterized. ...

Normalization strategies for real-time expression data in Chlamydia trachomatis

Since Chlamydia trachomatis is a genetically non-tractable pathogen, transcriptomics assumes a fundamental role for the better understanding of its biology. However, the suitability of endogenous controls for normalization of transcriptomic data in this bacterium still needs validation. We aimed to assess the stability of 10 genes for their potential use as endogenous controls in qPCR at both normal and stress ...

Molecular features underlying the higher ecological success of C. trachomatis E...

In the light of the >98% genomic similarity among Chlamydia trachomatis serovars, the higher worldwide ecological success of E and F is enigmatic. We intend to provide a quick overview of the molecular data that distinguish these from the remaining strains. Examples are: - E and F possess a similar chromosomal genetic make-up distinct from the remaining genotypes. Some loci linked to this independent co-segrega...

Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distin...

Background: Chlamydia trachomatis is one of the most disseminated human pathogens, for which no vaccine is available yet. Understanding the impact of the host pressure on pathogen antigens is crucial, but so far it was only assessed for highly-restricted geographic areas. We aimed to evaluate the evolutionary picture of the chlamydial key antigen (MOMP), which is one of the leading multi-subunit vaccine candida...

Chlamydia trachomatis in family planning. Is screening necessary?.

The authors used cellular cultures obtained from endocervix samples in order to determine the predominant factors of infection caused by Chlamydia trachomatis in a population of 391 women who attended a family planning consultation. The authors studied the relation between the infection and the following variables: age, geographical origin, social class, marital status, history of sexually transmitted diseases ...