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Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippoca...
Lopes, A.; Torres, D. B.; Rodrigues, Ana João; Cerqueira, João; Pêgo, José M.; Sousa, Nuno; Gontijo, J. A. R.; Boer, P. A.Studies have demonstrated that nutrient deficiency during pregnancy or in early postnatal life results in structural abnormalities in the offspring hippocampus and in cognitive impairment. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairments associated with structural changes in the hippocampus, we carried out a detailed morphometric analysis of the hippo...
Maternal undernutrition and the offspring kidney: from fetal to adult life
Mesquita,F.F.; Gontijo,J.A.R.; Boer,P.A.Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure to fetal glucocorticoid, alterations in the components of the renin-angiotensin system, apoptosis, and DNA methylation. A low-protein diet during gestation decreases the activity of placental 11...
Consequences of cerebroventricular insulin injection on renal sodium handling i...
Oliveira,P.C.; Michelotto,J.B.; Zapparoli,A.; Boer,P.A.; Gontijo,J.A.R.In the present study, we investigated the effects of acute intracerebroventricular (icv) insulin administration on central mechanisms regulating urinary sodium excretion in simultaneously centrally NG-nitro-L-arginine methylester (L-NAME)-injected unanesthetized rats. Male Wistar-Hannover rats were randomly assigned to one of five groups: a) icv 0.15 M NaCl-injected rats (control, N = 10), b) icv dose-response ...
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