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Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolish...
Carvalho, Ana Franky; Bockstaele, Elisabeth J. VanThe cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The present study was carried out to define the adrenergic receptor subtype involved in mediating cannabinoid-induced behavio...
Contribution of limbic norepinephrine to cannabinoid-induced aversion
Carvalho, Ana Franky; Reyes, Arith-Ruth S.; Sterling, Robert C.; Unterwald, Ellen; Bockstaele, Elisabeth J. VanRATIONALE: The cannabinoid system has risen to the forefront in the development of novel treatments for a number of pathophysiological processes. However, significant side effects have been observed in clinical trials raising concerns regarding the potential clinical utility of cannabinoid-based agents. Understanding the neural circuits and neurochemical substrates impacted by cannabinoids will provide a better...
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