Currently the safe and responsible use of antibiotics is a world-wide concern as it promotes prevention of the increasing emergence of multiresistant bacterial strains. Considering that there is a noticeable decline of the available antibiotic pipeline able to combat emerging resistance in serious infection a major concern grows around the prosthetic joint infections once the available commercial antibiotic loa...
Background: Children born before 32 weeks or very low birth weight have a high risk for neurodevelopmental impairment. Aim: To analyze the condition of extreme low birth infants (weighing 1000g or less), born in the years 2005 and 2006, and included in the Portuguese National Very Low Birth Weight Network. Results: A total of 163 children were evaluated, 49.1% of which were males with a mean gestational age 27 ...
Introdução: As crianças que nascem antes das 32 semanas ou com peso inferior a 1500g apresentam um elevado risco de sequelas no seu neurodesenvolvimento. Objectivo: Analisar a situação do crescimento e desenvolvimento neurosensorial das crianças com peso igual ou inferior a 1000g nascidas nos anos de 2005 e 2006 incluídas no registo nacional do muito baixo peso. Resultados: Das 163 crianças avaliadas, 49,1% e...
Introduction: Cytokines regulate the growth, function and differentiation of cells and help to steer immune response and inflammation. In this study we focused our attention in two proinflammatory cytokines: IL-6 and TNFa. It is known that their overexpression is responsible for initiation, maintenance and recurrence of skin lesions in psoriatic patients. Therefore, it is important to investigate genetic biomar...
Introduction: Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the world population. Patients with psoriasis (Ps) have higher prevalence of lipid disorders when compared to unaffected individuals. These patients, especially those with severe and prolonged disease, have an increased morbidity and mortality from cardiovascular events. Apolipoprotein E (ApoE), a protein involved in lipid metaboli...
A forma como a ciência é ensinada nas escolas afecta profundamente a percepção que os estudantes têm do mundo que os rodeia e consequentemente a escolha de uma futura carreira nas ciências. Por outro lado, a abertura da escola à comunidade envolvente, proporciona as condições para a sua participação activa na vida escolar, assim como a promoção do sucesso escolar, através da formação integral dos alunos, dotand...
An analytical method suitable for an antioxidant sensor is presented following the response of these substances to an extensive oxidative attack imposed by electrochemical means. The electrochemical assay simulates the action of a reactive oxygen species (ROS) by means of electrolyses carried out at a potential which is settled at the formal potential of the ROS. The antioxidant activities of trolox and ascorb...
This study aims to find out a vascular plant species that accumulate relatively high concentrations of arsenic (As) for its use as phytoremediator ar abandoned and contaminated mining areas, such as São Domingos mines (Portugal). The assessement of As contamination levels in soils and plants of other similar sites in the north of the coutry (Castromil ando Poço de Freitas) was also conducted and the sample anal...
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