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Sustained remission from depressive-like behavior depends on hippocampal neurog...
Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, NunoWe thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS. ; Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor ...
Perceived stress in obsessive-compulsive disorder is related with obsessive but...
Morgado, Pedro; Freitas, D.; Bessa, J. M.; Sousa, Nuno; Cerqueira, JoãoObsessive–compulsive disorder (OCD) is achronic psychiatric disorder characterized by recurrent intrusive thoughts and/or repetitive compulsory behaviors. This psychiatric disorder is known to be stress responsive, as symptoms increase during periods of stress but also because stressful events may precede the onset of OCD. However, only a few and inconsistent reports have been published about the stress percept...
Cell genesis and dendritic plasticity : a neuroplastic pas de deux in the onset...
Pinheiro, António Mateus; Patrício, P.; Bessa, J. M.; Sousa, Nuno; Pinto, LuísaBrain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from depressive-like behavior. However, the neurobiological significance of neuroplastic phenomena in this context is sti...
Immuno-Golgi as a tool for analyzing neuronal 3D-dendritic structure in phenoty...
Pinto, Luísa; Pinheiro, António Mateus; Morais, Mónica; Bessa, J. M.Characterization of neuronal dendritic structure in combination with the determination of specific neuronal phenotype or temporal generation is a challenging task. Here we present a novel method that combines bromodioxyuridine (BrdU) immunohistochemistry with Golgi-impregnation technique; with this simple noninvasive method, we are able to determine the tridimensional structure of dendritic arborization and spi...
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M.; Mesquita, Ana Raquel Marcelino; Oliveira, M??rio; P??go, Jos?? M.; Cerqueira, Jo??o; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoDepression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood [assessed with the forced-swimming (FST) and sucrose consumption tests (SCT)], anxiety [elevated-plus maze (EPM) and novelty suppressed feeding (NSF) tests]...
Neuropathic pain is associated with depressive behaviour and induces neuroplast...
Gonçalves, Leonor; Silva, Rui Jorge; Ribeiro, Filipa Pinto; Pêgo, José M.; Bessa, J. M.; Pertovaara, Antti; Sousa, Nuno; Almeida, ArmandoChronic pain is associated with the development of affective disorders but the underlying mechanisms are not fully understood. Changes in brain centres implicated in both emotional and pain processing are likely to be critical in the interplay of pain control and affective emotional behaviour. In the present study, we assessed emotional behaviour and performed a structural analysis of the amygdala (AMY) in neur...
Morphological correlates of corticosteroid-induced changes in prefrontal cortex...
Cerqueira, João; Pêgo, José M.; Taipa, Ricardo; Bessa, J. M.; Almeida, O. F. X.; Sousa, NunoImbalances in the corticosteroid milieu have been implicated in several neuropsychiatric disorders, including depression and schizo-phrenia. Prefrontal cortex (PFC) dysfunction is also a hallmark of these conditions, causing impairments in executive functions such as behavioral flexibility and working memory. Recent studies have suggested that the PFC might be influenced by corticosteroids released during stres...
Age-related qualitative shift in emotional behaviour : paradoxical findings aft...
Bessa, J. M.; Oliveira, M.; Cerqueira, João; Almeida, O. F. X.; Sousa, NunoSeveral variables, including age, are known to influence anxiety. Previous exposure to the elevated-plus maze (EPM) is known to modify emotional behaviour as retesting in the EPM at a standard age of 3 months increases open-arm avoidance and attenuates the effects of anxiolytic drugs. This study analysed whether similar results are obtained when older animals are subjected to these experimental paradigms. Overa...
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