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Nonproliferative retinopathy in diabetes type 2. Initial stages and characteriz...
Cunha-Vaz, JG; Bernardes, RCThis review addresses the initial stages of nonproliferative diabetic retinopathy in diabetes type 2. The natural history of the initial lesions occurring in the diabetic retina has particular relevance for our understanding and management of diabetic retinal disease, one of the major causes of vision loss in the western world. Diabetic retinal lesions are still reversible at this stage opening entirely new opp...
Macular alterations after small-incision cataract surgery
Lobo, CL; Faria, PM; Soares, MA; Bernardes, RC; Cunha-Vaz, JGPURPOSE: To characterize macular edema that occurs after uneventful cataract surgery. SETTING: Centre of Ophthalmology, University Hospital, Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. METHODS: Thirty-two eyes of 32 patients had uneventful phacoemulsification with implantation of a foldable intraocular lens. Postoperatively, patients were e...
Alterations of retinal capillary blood flow in preclinical retinopathy in subje...
Ludovico, J; Bernardes, RC; Pires, I; Figueira, J; Lobo, CL; Cunha-Vaz, JGBACKGROUND: To identify alterations of retinal capillary blood flow in the papillomacular area in preclinical diabetic retinopathy using the Heidelberg scanning laser Doppler flowmeter. METHODS: Ten eyes from ten patients with type 2 diabetes and no lesions visible on fundus photography (level 10 of Wisconsin grading) and ten eyes from ten healthy subjects of similar age range were examined with the HRF. Intrav...
Retinal thickness in eyes with mild nonproliferative retinopathy in patients wi...
Pires, I; Bernardes, RC; Lobo, CL; Soares, MA; Cunha-Vaz, JGOBJECTIVE: To compare measurements of retinal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus using 2 different techniques: the retinal thickness analyzer (RTA) and optical coherence tomography (OCT). METHODS: Twenty-eight eyes from 28 patients with type 2 diabetes mellitus and mild nonproliferative retinopathy were classified according to the Wisconsin gradin...
One-year follow-up of blood-retinal barrier and retinal thickness alterations i...
Lobo, CL; Bernardes, RC; Faria de Abreu, JR; Cunha-Vaz, JGOBJECTIVE: To examine the 1-year alterations of the blood-retinal barrier and changes in retinal thickness occurring in the macular region in patients with type 2 diabetes mellitus and mild nonproliferative retinopathy. METHODS: We classified 12 eyes of 12 patients with type 2 diabetes mellitus and mild nonproliferative retinopathy by 7-field stereoscopic fundus photography, levels 20 and 35 of Wisconsin gradi...
Alterations of the blood-retinal barrier and retinal thickness in preclinical r...
Lobo, CL; Bernardes, RC; Cunha-Vaz, JGOBJECTIVE: To identify alterations of the blood-retinal barrier by mapping retinal fluorescein leakage into the vitreous and changes in retinal thickness occurring in the macular region in preclinical diabetic retinopathy. METHODS: Ten eyes from 10 patients with type 2 diabetes and no lesions visible on fundus photography (level 10 of Wisconsin grading) were examined with the retinal leakage analyzer (RLA) (Co...
Novel imaging techniques for diabetic macular edema
Lobo, CL; Bernardes, RC; Faria de Abreu, JR; Cunha-Vaz, JGRetinal edema should be defined as any increase of water of the retinal tissue resulting in an increase in its volume. It may be of cytotoxic or vasogenic origin. Development of vasogenic macular edema is dependent on a series of factors such as blood pressure, blood-retinal barrier permeability, retinal cell damage, retinal tissue osmotic pressure and retinal tissue compliance. Objective measurements of retina...
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