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The soluble HFE isoform – a regulator of iron absorption in the duodenum
Silva, Bruno; Ferreira, Joana; Santos, Vera; Sousa, Patícia; Baldaia, Cilénia; Serejo, Fátima; Faustino, PaulaObjective: Dietary iron absorption regulation is a key-step for body iron homeostasis. Once inside the enterocyte, iron is directed to the basolateral membrane being oxidized by hephaestin, which mediates iron efflux towards circulatory transferrin in cooperation with ferroportin. Besides the HFE full-length protein, the HFE gene codes for alternative splicing transcripts responsible for the synthesis of a solu...
Data: 2014
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Origem: Repositório Científico do Instituto Nacional de Saúde
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