Encontrados 26 documentos, a visualizar página 1 de 3
Hereditary spherocytosis and the (TA)nTAA polymorphism of UGT1A1 gene promoter ...
Rocha, Susana; Costa, Elísio; Belo, Luís; Santos-Silva, AliceLetter to the Editor
Plant aqueous extracts: Antioxidant capacity via haemolysis and bacteriophage
Gião, Maria S.; Leitão, Isabel; Pereira, Ana; Borges, André B.; Guedes, Catarina J.; Fernandes, João C.; Belo, Luís; Santos-Silva, Alice; Hogg, Tim A.The bacteriophage P22/Salmonella Typhimurium system, as well as human erythrocytes have been used to assay for protection, against forced oxidation caused by hydrogen peroxide, brought about by several aqueous extracts of selected adventitious plants grown in Portugal. This study proved, for the first time, that the aforementioned bacteriophage-based system is a suitable method to assess the antioxidant activit...
Antioxidant activity of chitooligosaccharides upon two biological systems: Eryt...
Fernandes, João C.; Eaton, Peter; Nascimento, Henrique; Gião, Maria S.; Ramos, Óscar S.; Belo, Luís; Santos-Silva, Alice; Pintado, Manuela E.Most of the reports to date on the antioxidant capacity of chitosans and chitooligosaccharides (COS) are based on strictly chemical methods. When studying antioxidants with potential in vivo applications, the method used to evaluate the antioxidant activity should be representative of the conditions in which the antioxidant might have a protective effect. In this work we evaluate the antioxidant activity of two...
Effect of recombinant human erythropoietin in a rat model of moderate chronic r...
Garrido, P.; Reis, Flávio; Costa, Elísio; Almeida, A.; Parada, B.; Teixeira-Lemos, E.; Santos, P.; Alves, R.; Sereno, J.; Pinto, R.; Tavares, C. A.Background/Aims: Chronic renal failure (CRF) patients develop anaemia, thus promoting cardiovascular complications, which seems to be favoured by the low kidney erythropoietin (EPO) production. The renal insufficiency degree might determine the moment to start recombinant human EPO (rhEPO) therapy. It has been attributed important non-hematopoietic effects to rhEPO, which might underlie cardio and renoprotectio...
Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydroge...
Rocha, Susana; Costa, Elísio; Coimbra, Susana; Nascimento, Henrique; Catarino, Cristina; Rocha-Pereira, Petronila; Quintanilha, Alexandre; Belo, LuísHuman erythrocyte peroxiredoxin 2 (Prx2) is a typical 2-cys cytosolic peroxiredoxin with thiol-dependent hydrogen peroxide scavenger activity. In a previous work, we reported Prx2 erythrocyte membrane linkage in some Hereditary Spherocytosis patients and that it seemed to be related to oxidative stress. The aim of the present work was to determine if Prx2 linkage to erythrocyte membrane could be induced by oxid...
Hepcidin serum levels and resistance to recombinant human erythropoietin therap...
Costa, Elísio; Swinkels, Dorine W.; Laarakkers, Coby M.; Rocha-Pereira, Petronila; Rocha, Susana; Reis, Flávio; Teixeira, Frederico; Miranda, VascoThis title was also presented orally at Clinical Biochemistry workshop,Faro, 29 Janeiro, 2010
Resistance to recombinant human erythropoietin therapy in haemodialysis patient...
Costa, Elísio; Belo, Luís; Quintanilha, Alexandre; Santos-Silva, AliceAnaemia is a common complication in haemodialysis patients. This condition is associated to a decreased bone marrow production of erythrocytes, mainly due to the inability of the failing kidneys to secrete erythropoietin (EPO). The introduction of recombinant human EPO (rhEPO) therapy led to a significant reduction in anaemia and improved patients’ quality of life. However, there is a marked variability in the ...
Erythropoietin promotes deleterious cardiovascular effects and mortality risk i...
Piloto, Nuno; Teixeira, Helena M.; Teixeira-Lemos, Edite; Parada, Belmiro; Garrido, Patrícia; Sereno, José; Pinto, Rui; Carvalho, Lina; Costa, ElísioAthletes who abuse recombinant human erythropoietin (rhEPO) consider only the benefit to performance and usually ignore the potential short and long-term liabilities. Elevated haematocrit and dehydratation associated with intense exercise may reveal undetected cardiovascular risk, but the mechanisms underlying it remain to be fully explained. This study aimed to evaluate the cardiovascular effects of rhEPO in r...
Resistance to recombinant human erythropoietin therapy in haemodialysis patients
Costa, Elísio; Lima, Margarida; Rocha, Susana; Pereira, Petronila Rocha; Reis, Flávio; Castro, Elisabeth; Teixeira, Frederico; Miranda, VascoTo better clarify the mechanism of resistance to recombinan thuman erythropoietin (rhEPO) therapy in haemodialysis patients, we studied systemic changes associated with resistance to rhEPO therapy in haemodialysis patients under rhEPO therapies, with particular interest on inflammation, leukocyte activation, iron status, oxidative stress and erythrocyte damage. We studied 63 chronic kidney disease (CKD) patient...
Inflammation, T-Cell phenotype, and inflammatory cytokines in chronic kidney di...
Costa, Elísio; Lima, Margarida; Alves, João; Rocha, Susana; Rocha-Pereira, Petronila; Castro, Elisabeth; Miranda, Vasco; Faria, Maria SameiroBackground Resistance to recombinant human erythropoietin (rhEPO) occurs in some chronic kidney disease (CKD) patients, which may be due to enhanced systemic inflammatory response and to the erythropoiesis-suppressing effect of pro-inflammatory cytokines, some of which are produced by T cells. Aim of study The aim of this study was to investigate the relationship between resistance to rhEPO therapy in hemodialy...
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