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Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine...

Janele, D; Lang, T; Capellino, S; Cutolo, M; Pereira da Silva, JA; Straub, RH

Estrogens at physiological concentrations are thought to play an immune-stimulating role, whereas androgens have an anti-inflammatory impact. However, their role on cytokine secretion in the presence or absence of cortisol has not been investigated. Furthermore, the role of hydroxylated estrogens downstream of 17beta-estradiol (E2) on secretion of tumor necrosis factor (TNF) is not known. In this study on perip...


Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatme...

Buttgereit, F; Pereira da Silva, JA; Boers, M; Burmester, GR; Cutolo, M; Jacobs, J; Kirwan, J

In rheumatology and other medical specialties there is a discrepancy between the widespread use and the imprecise designation of glucocorticoid treatment regimens. Verbal descriptions of glucocorticoid treatment regimens used in various phases of diseases vary between countries and institutions. Given this background, a workshop under the auspices of the EULAR Standing Committee on International Clinical Studie...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia