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T Cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio; Rodrigues, Bruno Cerqueira; Roque, Susana; Silva, Palmira Barreira; Behar, Samuel M.; Neves, Margarida CorreiaThe thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
T cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio Nunes; Rodrigues, Bruno Miguel Cerqueira; Roque, Susana; Silva, Palmira Barreira da; Behar, Samuel M.The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
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