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Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
Bjerke,Lynn; Mackay, Alan; Nandhabalan, Meera; Burford, Anna; Jury, Alexa; Popov, Sergey; Bax, Dorine A.; Carvalho, Diana; Taylor, Kathryn R.Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A, occurring either at or close to key residues marked by methylation for regulation of transcription-K27 ...
Microsatellite instability in pediatric high grade glioma is associated with ge...
Pereira, Marta Viana; Lee, Alicia; Popov, Sergey; Bax, Dorine A.; Al-Sarraj, Safa; Bridges, Leslie R.; Stávale, João N.; Jones, Chris; Reis, R. M.The authors would like to thank Dr. Steve Jackson's Laboratory at the University of Cambridge for the MRE11 antibody and Dr. Sandra Costa from ICVS, University of Minho, for the disease-free controls DNA ; High grade gliomas (HGG) are one of the leading causes of cancer-related deaths in children, and there is increasing evidence that pediatric HGG may harbor distinct molecular characteristics compared to adul...
Molecular and phenotypic characterisation of paediatric glioma cell lines as mo...
Bax, Dorine A.; Little, Suzie; Gaspar, Nathalie; Perryman, Lara; Marshall, Lynley; Viana, Marta Pereira; Jones, Tania A.; Williams, Richard D.Background: Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new targeted therapies is the relative lack of cell lines derived from childhood glioma patients, as it is unclear whether the well-established adult lines commonly used are representative of the unde...
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