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Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...

Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Ene...

Mitoxantrone (MTX) is a chemotherapeutic agent, which presents late irreversible cardiotoxicity. This work aims to highlight the mechanisms involved in the MTX-induced cardiotoxicity, namely the effects toward mitochondria using in vivo and in vitro studies. Male Wistar rats were treated with 3 cycles of 2.5 mg/kg MTX at day 0, 10, and 20. One treated group was euthanized on day 22 (MTX22) to evaluate the early...

Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 C...

Mitoxantrone (MTX) is a chemotherapeutic agent that emerged as an alternative to anthracycline therapy. However, MTX also causes late cardiotoxicity, being oxidative stress and mitochondrial-impaired function proposed as possible mechanisms. This work aimed to investigate the relevance of these mechanisms to the MTX toxicity in H9c2 cells, using therapeutic concentrations. The observed cytotoxicity of MTX was t...

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...

Tolerance and stress response of the saprobe macrofungi Macrolepiota procera to...

Nickel (Ni) is an essential element for many organisms however it is very toxic at high concentrations and also depending on the species. In macrofungi the mechanisms underlying their Ni-tolerance are poorly documented. We examined, for the first time, the participation of the antioxidative system in the Macrolepiota procera exposed to different Ni2+ concentrations and their relation with Ni-tolerance. The effe...

A utilização do cobre na protecção fitossanitária da oliveira e implicações na ...

Na protecção fitossanitária da oliveira, especialmente na luta contra doenças fúngicas, são utilizados pesticidas com diferentes formulações de cobre. A utilização destes produtos e permitida nos diferentes sistemas de protecção do olival, quer seja em produção convencional, em produção integrada ou no modo de produção biológico, o que os torna de utilização praticamente generalizada. Neste sentido, o presente ...

Chemical reactivity of paraquat with the previously validated antidote, sodium ...

Reactivity of paraquat with sodium salicylate: Formation of stable complexes

Sodium salicylate (NaSAL) has been shown to be a promising antidote for the treatment of paraquat (PQ) poisonings. The modulation of the pro-oxidant and pro-inflammatory pathways, as well as the antithrombogenic properties of NaSAL are probably essential features for the healing effects provided by this drug. Nevertheless, a possible direct chemical reactivity between PQ and NaSAL is also a putative pathway to ...

Time dependent activation of transcription factors in freshly isolated cardiomy...

http://www.sciencedirect.com/science/article/B6TCR-4PKH640-H/1/d0195093d7c07e99f21ac2b29efae75f

Antioxidant activity and phenolic contents of Olea europaea L. leaves sprayed w...

Olive trees (Olea europaea L. Cv. Cobranc¸osa) from the northeast of Portugal were sprayed with three different copper formulations [bordeaux mixture (copper sulphate + calcium hydroxide - 20% Cu), copper hydroxide (40% Cu) and copper oxychloride (50% Cu)] to control olive fungal diseases. The residues of copper in olive leaves, harvested at different times, were evaluated by atomic absorption spectrometry. At ...