RCAAP - Repositório Científico de Acesso Aberto de Portugal

Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutat...

Viana-Pereira, M; Lopes, JM; Little, S; Milanezi, F; Basto, D; Pardal, F; Jones, C; Reis, RM

BACKGROUND: Patients with malignant gliomas do not respond to any current therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene mutation. EGFR inhibitors are being tried in gliomas, yet the molecular determinants of therapeutic response are unclear. MATERIALS AND METHODS: EGFR overexpress...

Data: 2008 | Origem: Repositório Científico do Hospital de Braga

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Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutat...

Viana-Pereira, M; Lopes, JM; Little, S; Milanezi, F; Basto, D; Pardal, F; Jones, C; Reis, RM

BACKGROUND: Patients with malignant gliomas do not respond to any current therapy. Epidermal growth factor receptor (EGFR) controls several oncogenic processes, being frequently up-regulated in gliomas due to overexpression, gene amplification and gene mutation. EGFR inhibitors are being tried in gliomas, yet the molecular determinants of therapeutic response are unclear. MATERIALS AND METHODS: EGFR overexpress...

Data: 2008 | Origem: Repositório Comum

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Mutation analysis of B-RAF gene in human gliomas.

Basto, D; Trovisco, V; Lopes, JM; Martins, A; Pardal, F; Soares, P; Reis, RM

The RAS/RAF/MEK/ERK kinase pathway is pivotal in the transduction of mitogenic stimuli from activated growth factor receptors, which regulates cell proliferation, survival, and differentiation. Up-regulation of this pathway due to RAS mutations is found in approximately 30% of human tumors. Recently, activating mutations of B-RAF were identified in a large proportion of human cancers. Gliomas are the most frequ...

Data: 2005 | Origem: Repositório Científico do Hospital de Braga

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Mutation analysis of B-RAF gene in human gliomas.

Basto, D; Trovisco, V; Lopes, JM; Martins, A; Pardal, F; Soares, P; Reis, RM

The RAS/RAF/MEK/ERK kinase pathway is pivotal in the transduction of mitogenic stimuli from activated growth factor receptors, which regulates cell proliferation, survival, and differentiation. Up-regulation of this pathway due to RAS mutations is found in approximately 30% of human tumors. Recently, activating mutations of B-RAF were identified in a large proportion of human cancers. Gliomas are the most frequ...

Data: 2005 | Origem: Repositório Comum

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