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NMR and molecular modelling studies on elastase inhibitor-peptides for wound ma...
Barros, Sandra Cerqueira; Louro, Ricardo O.; Micaelo, N. M.; Martins, José A.; Marcos, João Carlos; Paulo, Artur CavacoProteases play an important and critical role in the physiological process of wound repair. However, excessive and unregulated release of proteolytic enzymes (e.g., elastase) mediates abnormal degradation of healthy tissues, which leads to inflammatory disorders such as chronic wounds. Thus, it is of therapeutic interest to develop novel synthetic inhibitor-peptides of elastase, which can restore the balance be...
Characterization of potential elastase inhibitor-peptides regulated by a molecu...
Barros, Sandra Cerqueira; Martins, J. A. R.; Marcos, João Carlos; Paulo, Artur CavacoElastase plays an important role in wound healing process, degrading damaged tissue and allowing complete tissue recovery. The levels of human neutrophil elastase (HNE) are usually controlled by endogenous inhibitors. However, in the presence of high levels of elastase, like the ones present in chronic wounds, the inhibitors cannot overcome this overproduction and the enzyme starts to degrade the surrounding he...
Influence of secretory leukocyte protease inhibitor (SLPI) basedeptides on elas...
Barros, Sandra Cerqueira; Martins, J. A. R.; Marcos, João Carlos; Paulo, Artur CavacoChronic nonhealing skin wounds, such as leg ulcers and pressure sores, represent a major clinical problem and a financial burden for the health care systems. Chronic wounds are characterized by prolonged inflammatory phase that results in high levels of elastase, reactive oxygen species (ROS), and diminished growth factor activity. Under normal physiological conditions, elastase is a powerful host defence and i...
Di-urea cross-linked poly(oxyethylene)/siloxane ormolytes for lithium batteries
Nunes, Sílvia; Zea Bermudez, V. de; Ostrovskii, David; Silva, Maria Manuela; Barros, Sandra Cerqueira; Smith, Michael John; Carlos, Luís; Rocha, JoãoPoly(oxyethylene)( POE)/siloxane hybrids (di-ureasils) doped with a wide concentration range of lithium triflate were investigated. The host matrix of these materials (d-U(2000)) is a sol-gel derived siliceous network to which POE chains with about 40 repeat units are bonded through urea linkages. Xerogels with n between 500 and 5 (where n is the molar ration of OCH2CH2 repeat units to lithium íons) were obtain...
Di-ureasil ormolytes doped with Mg2+ ions : part 1: morphological, thermal and ...
Nunes, Sílvia; Zea Bermudez, V. de; Silva, Maria Manuela; Barros, Sandra Cerqueira; Smith, Michael John; Morales, Enrique; Rocha, João; Carlos, LuísPoly(oxyethylene)(POE/siloxane-based materials incorporating magnesium triflate were prepared by the sol-gel process. The host Class II hybrid matrix (di-ureasil) employed was composed of a siliceous framework to which short POE chains were covalently bonded through urea linkages. Ormolytes with salt composition ranging from 500 to 1 were characterised. The nanohybrid with n = 20, thermally stable up to 360ºC, ...
Characterization of solid polymer electrolytes based on poly(trimethylenecarbon...
Silva, Maria Manuela; Barros, Sandra Cerqueira; Smith, Michael John; MacCallum, James R.The results of an investigation of a polymer electrolyte system based on the poly(trimethylene carbonate) host matrix, designated as p(TMC), with lithium tetrafluoroborate guest salt are described in this presentation. Electrolytes with lithium salt compositions with n between 3 and 80 (where n represents the number of (O=COCH2CH2CH2O) units per lithium ion) were prepared by co-dissolution o...
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