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Monozygotic twin sisters discordant for familial hemiplegic migraine
Barros, J.; Barreto, R.; Brandão, A.; Domingos, J.; Damásio, J.; Ramos, C.; Lemos, C.; Sequeiros, J.; Alonso, I.; Pereira-Monteiro, J.Background: The high concordance rate of migraine in monozygotic twin pairs has long been recognised. In the current study, we present a monozygotic twin pair discordant for familial hemiplegic migraine (FHM). Case presentations: We evaluated 12 adult family members in 2012. The twin pair was separately examined by neurologists at different time points. Mutation screening was performed for known FHM-related gen...
Interaction between γ-Aminobutyric Acid A Receptor Genes: New Evidence in Migra...
Quintas, M.; Neto, J.; Pereira-Monteiro, J.; Barros, J.; Sequeiros, J.; Sousa, A:; Alonso, I.; Lemos, C.Migraine is a common neurological episodic disorder with a female-to-male prevalence 3- to 4-fold higher, suggesting a possible X-linked genetic component. Our aims were to assess the role of common variants of gammaaminobutyric acid A receptor (GABAAR) genes, located in the X-chromosome, in migraine susceptibility and the possible interaction between them. An association study with 188 unrelated cases and 286 ...
LONG TERM EFFECT OF TILLAGE SYSTEM AND CROP RESIDUE MANAGEMENT ON SOIL CARBON C...
Carvalho, Mário; Basch, Gottlieb; Calado, J.M.G.; Barros, J.F.CUnder Mediterranean conditions, soils under conventional tillage farming usually have very low contents of organic matter. This situation is due to intensive soil tillage, low biomass production under rainfed conditions, and removal of cereal straw for alternative use off the field. In order to study strategies to improve soil organic matter content (SOM), a long term experiment (11 years) was established in 19...
Impact of soil tillage and land use on soil organic carbon decline under Medite...
Basch, G.; Calado, J.; Barros, J.; Carvalho, M.Soils under Mediterranean climate conditions frequently have low to very low levels of soil organic matter (SOM), as a result of low biomass production under the predominantly rainfed conditions and the intensive tillage operations commonly practiced. In order to assess both short and long-term impacts of soil tillage and land use on soil organic carbon, two sets of experiments were performed. One consisted in ...
Seismic strengthening of beam-column joints with multidirectional CFRP laminates
Coelho, M.; Fernandes, P.; Melo, J.; Sena-Cruz, J.; Varum, H.; Barros, J.; Costa, A.An experimental program was carried out to analyse the potentialities of a technique based on the use of multidirectional CFRP laminates (MDL-CFRP) for the seismic repair and strengthening of reinforced concrete (RC) beam-column joints. This experimental program comprises cyclic tests on three full-scale RC joints, representative of interior beam-column connections in buildings. The joints were initially submit...
Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2)
Barros, J.; Mendes, A.; Matos, I.; Pereira-Monteiro, J.Abstract INTRODUCTION: Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings. CASE REPORT: Male, 48 years old, with an aura that included complex...
Migraine-induced epistaxis and sporadic hemiplegic migraine: unusual features i...
Barros, J.; Damásio, J.; Tuna, A.; Pereira-Monteiro, J.Abstract Background: Since the mid-19th century, epistaxis and migraine have been occasionally associated with each other. Nevertheless, we found only two cases in the contemporary medical literature. Sporadic hemiplegic migraine is a subtype of migraine with reversible motor deficits, without similar episodes in relatives. Case: We describe a 47-year-old male with a history of migraine with a scintillating ...
Assessing risk factors for migraine: differences in gender transmission
Lemos, C.; Alonso, I.; Barros, J.; Sequeiros, J.; Pereira-Monteiro, J.; Mendonça, D.; Sousa, A.Abstract AIM: Our aim was to assess which specific factors are contributing to an increased risk of migraine in a group of 131 Portuguese families. METHODS: We studied 319 first-degree relatives, using a multilevel approach to account for the dependency among members from the same family. We included in the model relative's gender, the proband's gender and age-at-onset, to evaluate if any of these variables we...
Seismic retrofit of RC beam-column joints using the MF-EBR strengthening technique
Coelho, M.; Fernandes, P.; Melo, J.; Sena-Cruz, J.; Varum, H.; Barros, J.; Costa, A.The strengthening technique based on the application of multi-directional laminates of CFRP (MDL-CFRP) simultaneously glued and anchored to the surface of the elements to be strengthened has been recently proposed. This technique was designated Mechanically Fastened and Externally Bonded Reinforcement (MF-EBR) and combines the fasteners from the MF-FRP technique with the externally glued properties from the EBR...
A role for endothelin receptor type A in migraine without aura susceptibility? ...
Lemos, C.; Neto, J.; Pereira-Monteiro, J.; Mendonça, D.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.Abstract BACKGROUND AND PURPOSE: Migraine is a common neurological disabling disorder, and anomalies of vascular function have been implied in its pathophysiology. Several findings point to a possible role of the endothelin receptor type A (EDNRA) in migraine. We aim to assess the involvement of endothelin receptor type A (EDNRA) in migraine susceptibility in a sample of Portuguese migraineurs. METHODS: Three...
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