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Endothelialization of chitosan porous conduits via immobilization of a recombin...
Amaral, I. F.; Neiva, I.; Silva, F. Ferreira da; Sousa, S. R.; Piloto, A. M.; Lopes, C. D. F.; Barbosa, Mário A.; Kirkpatrick, C. J.; Pêgo, A. P.The present study aimed to develop a pre-endothelialized chitosan (CH) porous hollowed scaffold for application in spinal cord regenerative therapies. CH conduits with different degrees of acetylation (DA; 4% and 15%) were prepared, characterized (microstructure, porosity and water uptake) and functionalized with a recombinant fragment of human fibronectin (rhFNIII7–10). Immobilized rhFNIII7–10 was characterize...
Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels
Ferreira, Lino; Rafael, Ana; Lamghari, Meriem; Barbosa, Mario A.; Gil, Maria H.; Cabrita, António M. S.; Dordick, Jonathan S.The biocompatibility of chemoenzymatically generated dextran-acrylate hydrogels has been evaluated in vitro, using human foreskin fibroblasts, and in vivo, by subcutaneous and intramuscular implantation in Wistar rats for up to 40 days. In vitro tests show that hydrogel extracts only minimally reduced (<10%) the mitochondrial metabolic activity of fibroblasts. Direct contact of the hydrogels with cells induced ...
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