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Gene expression regulation by upstream open reading frames and human disease
Barbosa, Cristina; Peixeiro, Isabel; Romão, LuísaUpstream open reading frames (uORFs) are major gene expression regulatory elements. In many eukaryotic mRNAs, one or more uORFs precede the initiation codon of the main coding region. Indeed, several studies have revealed that almost half of human transcripts present uORFs. Very interesting examples have shown that these uORFs can impact gene expression of the downstream main ORF by triggering mRNA decay or by ...
Translational control by an upstream open reading frame in the human erythropoi...
Barbosa, Cristina Maria Botelho da Rocha, 1986-Tese de doutoramento, Biologia (Biologia Molecular), Universidade de Lisboa, Faculdade de Ciências, 2013 ; Os estudos da regulação da expressão génica têm revelado elevada complexidade e diversidade de processos responsáveis por uma correta definição das características dos organismos e por um aumento de versatilidade e adaptação dos mesmos. Apesar da regulação transcricional ter sido realçada devido à sua imp...
Operacionalização de estratégias de inovação : proposta de um modelo de avaliação
Barbosa, Cristina Maria da SilvaEstágio realizado na Digitalflow - e orientado pelo Dr. Rui Patrício ; Tese de mestrado. Inovação e Empreendorismo Tecnológico. Faculdade de Engenharia. Universidade do Porto. 2012
Nonsense-mediated decay resistance of AUG-proximal nonsense-mutated transcripts...
Peixeiro, Isabel; Barbosa, Cristina; Romão, LuísaApresentação oral por convite. ; Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing a premature termination codon (PTC). The unified model for NMD proposes that the decision of NMD triggering is the outcome of the competition between the cytoplasmatic poly(A)-binding protein 1 (PABPC1) and the NMD effector UPF1 for the termination complex. Consequ...
An upstream open reading frame regulates de translational efficiency of the hum...
Barbosa, Cristina; Romão, LuísaAmong the various cis-acting elements present in the 5’ leader sequence of mRNAs there are upstream open reading frames (uORFs). Although their function is still poorly understood, they are known to downregulate the main ORF expression of several human transcripts that code for key regulatory genes. The human erythropoietin (EPO) is a glycoprotein that was initially characterized has a hormone mainly synthesiz...
Translational control of the human hemojuvelin via upstream open reading frames
Onofre, Claudia; Barbosa, Cristina; Romão, LuísaIron is an essential element for many biological reactions carried out by living systems. A tight regulation of systemic iron homeostasis is crucial to avoid the pathological conditions of iron deficiency or overload. Juvenile hemochromatosis, is an early-onset inherited disorder associated to iron overload caused by mutations on the hepcidin gene or in the gene encoding hemojuvelin (HJV). HJV is a glycosylphos...
Alternative polyadenylation and nonsense-mediated decay coordinately regulate t...
Martins, Rute; Proença, Daniela; Silva, Bruno; Barbosa, Cristina; Silva, Ana Luísa; Faustino, Paula; Romão, LuísaNonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons. However, several studies have shown that NMD also targets physiological transcripts that encode full-length proteins, modulating their expression. Indeed, some features of physiological mRNAs can render them NMD-sensitive. Human HFE is a MHC cl...
Interaction of PABPC1 with the translation initiation complex is critical to th...
Peixeiro, Isabel; Inácio, Ângela; Barbosa, Cristina; Silva, Ana Luísa; Liebhaber, Stephen; Romão, LuísaNonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have previously reported that mRNAs containing PTCs in close proximity to the translation initiation codon (AUG-proximal PTCs) can substantially evade NMD. Here, we exp...
Nonsense-mediated decay resistance of AUG-proximal nonsense-mutated transcripts...
Peixeiro, Isabel; Barbosa, Cristina; Silva, Ana Luísa; Romão, LuísaThe nonsense-mediated decay (NMD) is a surveillance mechanism that recognizes and rapidly degrades transcripts bearing a premature termination codon (PTC). Although in mammals the location of a PTC more than 50 nucleotides upstream the terminal exonexon junction has been pointed as a mark for NMD, it is now known that the physical distance between the PTC and cytoplasmic poly(A)-binding protein 1 (PABPC1) is a ...
Notoriedade e Valor da Marca dos Vinhos Verdes.
Barbosa, Cristina de SousaGestão Comercial ; Master in Sales Management
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