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Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer

Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation. SIRT1, which may act either as tumor suppressor or oncogene, reduces H2A.Z levels in cardiomyocytes, via proteasome-mediated degradation, and this mechanism might be impaired in prostate cancer cells due to sirtuin 1 downregulation. Thus, we aimed...

Thromboembolic Complications During Endovascular Treatment of Ruptured Intracra...

Thromboembolic phenomena are the most commonly reported complications during endovascular treatment of intracranial aneurysms with coils. Frequency of this complication varies in the literature, but authors reported rates ranging from 2.5 to 28%. Several mechanisms may be involved in the formation and migration of thrombus: it may be already existing inside the aneurysm and be dislocated and then migrate distal...

Flow Diverters Devices for Treatment of Intra-cranial Aneurysms – six Months Fo...

Endoluminal reconstruction with flow diverter devices represents an innovative technique in the treatment of intracranial aneurysms. These new stents, self-expandable and of low porosity, are released through the microcatherization of the parent artery. The main goal of these systems is thereby rebuilding the vessel wall and excluding the aneurysmal formation of the arterial circulation. We show the preliminary...

Motivação e adesão ao exercício físico : um estudo sobre o papel dos treinadore...

Introdução: Procuramos analisar a associação entre a frequência/adesão ao exercício físico (FAEF) em contexto de ginásios e health clubs (GHC) e os constructos previstos pela Teoria da Auto Determinação (TAD) em indivíduos que treinam com Treinador Pessoal (TP)e indivíduos que não treinam com TP. Método: Efetuámos uma revisão sistemática da literatura (RSL), seguida de um estudo observacional onde aplicámos que...

Complexity and emergence in societies of agents

Throughout the last decades, Darwin’s theory of natural selection has fuelled a vast amount of research in the field of computer science, and more specifically in artificial intelligence. The majority of this work has focussed on artificial selection, rather than on natural selection. In parallel, a growing interest in complexity science brought new modelling paradigms into the scene, with a focus on bottom-up ...

Análise de fiabilidade de estruturas

Dissertação para obtenção do Grau de Mestre em Engenharia Mecânica ; O trabalho elaborado consiste na criação de um programa informático, concebido em linguagem MATLAB, cujo principal objectivo é calcular a probabilidade de falha em estruturas compostas por vigas 2D, através do algoritmo FORM. Para a concepção do programa estudou-se alguma bibliografia sobre os vários domínios de conhecimentos envolvidos, nome...

Cinema e política na Primeira República

O arranque da produção cinematográfica em Portugal é contemporâneo da I República. Os filmes deste período sugerem uma representação pastoral do país, organizada em torno da adaptação de obras do cânone literário oitocentista português. A cidade e a contemporaneidade raramente são abordadas e a situação política do país jamais é referida. A única excepção foi Os Olhos da Alma (Roger Lion, 1923), produzido pela ...

Nacionalmente correcto: a invenção do cinema português

Comparison of Different Cemented Tungsten Carbides Applied to Particle-Board Ma...

Nowadays, many industrial companies have already established procedures to incorporate recycled products in their production lines. According to recent statistics, the wood recycling is growing exponentially, with products like MDF (medium density fiberboard), OSB (oriented strand board) or Particleboards being more and more important in the wood/furniture industry. Many times these products have different type...

Evolution of a multi-agent system in a cyclical environment

Abstract The synchronisation phenomena in biological systems is a current and recurring subject of scientific study. This topic, namely that of circadian clocks, served as inspiration to develop an agent-based simulation that serves the main purpose of being a proof-of-concept of the model used in the BitBang framework, that implements a modern autonomous agent model. Despite having been extensively studied, c...