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Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Silva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C.; Nunes, Susana; Baptista, Maria João Ribeiro Leite; Moura, Rute S.Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...
Perinatal cardiac function in congenital diaphragmatic hernia
Baptista, Maria João Ribeiro LeiteTese de Doutoramento Ciências da Saúde – Ciências Biológicas e Biomédicas ; Congenital diaphragmatic hernia (CDH) is a congenital condition with variable illness severity that usually requires complex and multidisciplinary care. The physiologic consequences of this defect may be mild and minimally symptomatic at birth, but almost half of CDH infants present with severe forms of the disease, with poor outcome a...
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