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Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Nogueira-Silva, C; Carvalho-Dias, C; Piairo, P; Nunes, S; Baptista, MJ; Moura, RS; Correia-Pinto, JAntenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT₁)...
Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Nogueira-Silva, C; Carvalho-Dias, C; Piairo, P; Nunes, S; Baptista, MJ; Moura, RS; Correia-Pinto, JAntenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT₁)...
Local Fetal Lung Renin-Angiotensin System as a Target to Treat Congenital Diaph...
Nogueira-Silva, C; Carvalho-Dias, E; Piairo, P; Nunes, S; Baptista, MJ; Moura, RS; Correia-Pinto, JAntenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT(1...
Local Fetal Lung Renin-Angiotensin System as a Target to Treat Congenital Diaph...
Nogueira-Silva, C; Carvalho-Dias, E; Piairo, P; Nunes, S; Baptista, MJ; Moura, RS; Correia-Pinto, JAntenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT(1...
Ghrelin reverses molecular, structural and hemodynamic alterations of the right...
Henriques-Coelho, T; Roncon-Albuquerque R, Jr.; Lourenço, AP; Baptista, MJ; Oliveira, SM; Brandão-Nogueira, A; Correia-Pinto, J; Leite-Moreira, AFGhrelin is an endogenous peptide that has a dual effect by activating specific receptors and by stimulating release of growth hormone. There is increasing evidence that ghrelin has a potent vasodilator effect. Recently, we demonstrated that exogenous administration of ghrelin modulates its endogenous levels and attenuates the majority of alterations induced by monocrotaline (MCT). In the present study, we evalu...
Endogenous production of ghrelin and beneficial effects of its exogenous admini...
Henriques-Coelho, T; Correia-Pinto, J; Roncon-Albuquerque R, Jr.; Baptista, MJ; Lourenço, AP; Oliveira, SM; Brandão-Nogueira, A; Teles, A; Fortunato, JMWe investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Adult Wistar rats randomly received a subcutaneous injection of MCT (60 mg/kg) or an equal volume of vehicle. One week later, animals were randomly assigned to receive a subcutaneous injection of ghrelin (100 mug/k...
Meconium dependence of bowel damage in gastroschisis
Correia-Pinto, J; Tavares, ML; Baptista, MJ; Henriques-Coelho, T; Estevão-Costa, J; Flake, AW; Leite-Moreira, AFBACKGROUND/PURPOSE: Increasing evidence of physiologic in utero defecation supports the hypothesis that bowel damage in gastroschisis may be meconium dependent. In this study, the author investigated the role of meconium on parameters of bowel damage in a fetal rat model of gastroschisis. METHODS: Pregnant rats underwent laparotomy at 18 1/2 days gestational age (GA). There were 4 experimental groups of 11 fetu...
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