OBJECTIVE: The aim of this study was to examine the distribution of endothelin-1 (ET-1) in the human placenta at different gestational ages and to determine whether differences in ET-1 immunoreactivity occurred in preeclamptic compared with uncomplicated pregnancies. METHODS: Localization of ET-1 was investigated by the immunoperoxidase technique in first-trimester, second-trimester, and term human placentas fr...
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