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Síndrome de Marfan — Manifestações Cardiovasculares

O Síndrome de Marfan (S.M.) é a alteração hereditária do tecido conjuntivo mais comum. É caracterizado por manifestações cardiovasculares, esqueléticas e oculares. O seu prognóstico depende principalmente das complicações cardiovasculares. Com o objectivo de avaliar as manifestações cardiovasculares do S.M. em idade pediátrica, os autores procederam à revisão dos processos clínicos das crianças seguidas na cons...

Qualidade de vida e prevenção da deficiência

Os A. situam, num contexto lato, a problemática da Deficiência, relacionando-a com Qualidade de vida e com o Stress enquanto determinantessignificativos dessa Qualidade de vida.A prevenção da deficiência, sobretudo entendida nas dimensões emocional e afectiva, passaria por uma intervençãoface ao vínculo e a uma homeostase bio-psico-social, modeladora dum stress eventualmente excessivo.Os A., por último, trazem ...

Remote Nodes topologies for hybrid WDM-ring TDM-tree passive optical networks

In this paper is presented a WDM-ring TDM-tree passive optical network able to provide more than 1024 users spread over 100km with a symmetrical bandwidth of 100Mbps. A set of optically fed passive remote nodes are also presented able to provide increased efficiency and resili90ency. ; In this paper is presented a WDM-ring TDM-tree passive optical network able to provide more than 1024 users spread over 100km ...

Development and evaluation of a novel topical treatment for acne with azelaic a...

Azelaic acid (AzA) is used in the treatment of acne. However, side effects and low compliance have been associated with several topical treatments with AzA. Nanotechnology presents a strategy that can overcome these problems. Polymeric nanoparticles can control drug release and targeting and reduce local drug toxicity. The aim of this study was to produce and evaluate an innovative topical treatment for acne wi...

Endovascular management of non maturing dyalisis vascular access

Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, le...

A photodynamic effect occurs when photosensitiser molecules absorb light and dissipate the absorbed energy by transferring it to biological acceptors (usually oxygen), generating an excess of reactive species that are able to force cells into death pathways. Several tropical diseases present physiopathological aspects that are accessible to the application of a photosensitiser and local illumination. In additio...

Lynch Syndrome without mutation of Mismatch Repair Genes: The other face of the...

Background: Lynch Syndrome (LS) is the most frequent form of hereditary colorectal cancer (CRC) and derives from germinative mutations in the mismatch repais genes (MMR). The clinical diagnosis is based on Amsterdam criteria (AC) but definitive diagnostic is based on the identification of a MMR gene mutation. Of these, MLH1 and MSH2 are the most frequent, followed by MSH6 and rarely by other genes (PMS1 and PMS...

Kalirin: a novel genetic risk factor for ischemic stroke

Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and metabolic phenotypes, but no studies have yet been perfo...

Primary Malignant Peritoneal Mesothelioma Associated with Renal Cell Carcinoma....

O Mesotelioma peritoneal maligno é um tumor maligno relacionado frequentemente com exposição prolongada a fibras de amianto, de mau prognóstico, de diagnóstico geralmente tardio, face à pouca expressão clínica na fase inicial da doença. Como o mesotelioma evolui geralmente só na cavidade peritoneal, doentes seleccionados poderão ter maior sobrevivência se for possível a peritonectomia extensa e quimioterapia hi...

Mitochondrial haplogroup H1 is protective for ischemic stroke in Portuguese pat...

BACKGROUND: The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to ...