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Hiperplasia Congénita da Suprarrenal de Expressão Tardia por Deficiência de 21-...

Vieira, A; Paiva, S; Baptista, C; Ruas, L; Silva, J; Gonçalves, J; Carrilho, F; Carvalheiro, M

The deficiency of the enzyme 21-hydroxylase (21-HO) is responsible for about 90% to 95% of all cases of congenital adrenal hyperplasia (HCSR). This disorder is one of the most frequent hereditary illnesses of autosomal recessive trait. The illness can be presented in two clinical forms: 1 - classic, subdivided in saltwasting form and simple virilizing form; 2 - nonclassic or late-onset. The severity of the illn...


Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis o...

Delgado, T. C.; Barosa, C.; Castro, M. M. C. A.; Geraldes, C. F. G. C.; Bastos, M.; Baptista, C.; Fagulha, A.; Barros, L.; Mota, A.; Carvalheiro, M.

The contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after 2H2O ingestion by Bayesian analysis of the position 2 and 5 2H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide. Six controls and 10 kidney transplant (KTx) patients with cyclosporine A (CsA) immunosuppressant therapy were studied. Seven KTx patients were lean and euglyc...


Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis o...

Delgado, TC; Barosa, C; Castro, MM; Geraldes, CF; Bastos, M; Baptista, C; Fagulha, A; Barros, L; Mota, A; Carvalheiro, M; Jones, JG; Merrit, M

The contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after (2)H(2)O ingestion by Bayesian analysis of the position 2 and 5 (2)H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide. Six controls and 10 kidney transplant (KTx) patients with cyclosporine A (CsA) immunosuppressant therapy were studied. Seven KTx patients were lean and ...


Natural immobilisation of microorganisms for continuous ethanol production

Baptista, C. M. S. G.; Cóias, J. M. A.; Oliveira, A. C. M.; Oliveira, N. M. C.; Rocha, J. M. S.; Dempsey, M. J.; Lannigan, K. C.; Benson, P. S.

Using a growth medium based on cane blackstrap molasses, we compared ethanol production by two strains of Saccharomyces cerevisiae that were immobilized in polyurethane foam cubes in a fluidised-bed fermenter. One strain (NCYC 1119) was adhesive and extremely flocculent, whilst the other strain was not adhesive and only weakly flocculent. The strong flocs of NCYC 1119 caused blockage of the bed, so that stable ...


Noninvasive analysis of hepatic glycogen kinetics before and after breakfast wi...

Jones, JG; Fagulha, A; Barosa, C; Bastos, M; Barros, L; Baptista, C; Caldeira, MM; Carvalheiro, M

The contributions of hepatic glycogenolysis to fasting glucose production and direct pathway to hepatic glycogen synthesis were quantified in eight type 1 diabetic patients and nine healthy control subjects by ingestion of (2)H(2)O and acetaminophen before breakfast followed by analysis of urinary water and acetaminophen glucuronide. After overnight fasting, enrichment of glucuronide position 5 relative to body...


A diabetes na quarta idade: a nossa realidade

Paiva, I; Baptista, C; Ribeiro, C; Leitão, P; Carvalheiro, M

AIM: To evaluate the impact of the aging of our population in the growing of diabetes prevalence, among patients treated inward at our department. MATERIAL AND METHODS: The clinical files of 242 diabetics older than eighty years, treated between 1999 and 2002 were studied retrospectively. Demographic (sex, age, year of first contact), clinical (causes of admission, co-morbidities, duration of diabetes, previous...


Transplantação pancreática

Bastos, M; Campos, MV; Baptista, C; Alves, R; Bastos, C; Mota, A; Carvalheiro, M; Furtado, AL; Ruas, A

A clinic case of simultaneous pancreas/kidney transplantation on a type 1 diabetic patient is described. A six years follow-up was made with both organs functionating and a good quality of live.Then the authors make a review of the available surgical techniques, indications and complications of this form of treatment. A comparison between the Portuguese and the International experience was discussed.


Síndroma de Cushing ACTH-dependente: estudo retrospectivo

Paiva, I; Ribeiro, C; Gomes, L; Baptista, C; Gomes, F; Rito, M; Rebelo, O; Marnoto, D; Moura, C; Leitão, F; Carvalheiro, M

AIM: To evaluate the characteristics and outcomes of the patients diagnosed as ACTH-dependent Cushing syndrome, registered in the department. MATERIAL AND METHODS: We reviewed the files of forty-three patients followed from 1974 to 2002. RESULTS: A progressive rise in the number of patients diagnosed was found, being 80% females. Clinical suspicion was based mostly on the typical fat distribution; hirsutism and...


Kidney transplantation and posttransplantation diabetes: nutritional evaluation

Loureiro, H; Silva, RS; Machado, C; Bastos, M; Baptista, C; Alves, R; Mota, A; Furtado, AL; Carvalheiro, M; Saldanha, MH


Kidney transplantation and diabetes: posttransplantation malignancy

Bastos, M; Baptista, C; Campos, MV; Alves, R; Freitas, L; Bastos, C; Leitão, P; Lemos, MC; Mota, A; Furtado, AL; Carvalheiro, M


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia