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How to decipher a microbial puzzle on microbial control : hands on
Azevedo, Maria Manuel; Pinheiro, Céline; Miranda, Isabel; Baltazar, FátimaHow to decipher a microbial puzzle on microbial control: hands on ; Antibiotics are among the most commonly prescribed drugs, but they are often misused, contributing to bacterial resistance, being an important public health problem, with clinical/economic impacts. Aiming to contribute to convey information to students on Microbiology/antibiotic use, we developed different teaching activities, with 6th and 9th...
Characterization of monocarboxylate transporters (MCTs) expression in soft tiss...
Pinheiro, Céline; Penna, Valter; Santos, Filipa Morais; Abrahão-Machado, Lucas F.; Ribeiro, Guilherme; Curcelli, Emílio C.; Olivieri, Marcus V.Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and therapeutic response. As highly glycolytic tumors, we hypothesized that sarcomas should present an increased expression of lactate transporters (M...
A lactate shuttle system between tumour and stromal cells is associated with po...
Pértega-Gomes, Nelma; Vizcaíno, José R.; Attig, Jan; Jurmeister, Sarah; Lopes, Carlos; Baltazar, FátimaBackground In a malignant tumour, cancer cells are embedded in stromal cells, namely cancer-associated fibroblasts (CAFs). These CAFs are now accepted as important players in cancer dynamics, being involved in tumour growth and progression. Although there are various reports on the interaction between tumour and stromal cells, the clinico-pathological significance of this cross-talk is still largely unknown. In...
Monocarboxylate transporters (MCTs) in gliomas : expression and exploitation as...
Gonçalves, Vera M.; Honavar, Mrinalini; Pinheiro, Céline; Martinho, Olga; Pires, Manuel Melo; Pinheiro, Célia; Cordeiro, Michelle; Bebiano, GilBackground. Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs) play a major role in the maintenance of the glycolytic metabolism through the proton-linked transmembrane transport of lactate. However, their role in gliomas is poorly studied. Thus, we aimed to characterize the expression of MCT1, MCT4, and their chaperone CD147 and to assess the therapeutic impact of MCT inhibition in...
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer i...
Santos, Luísa Filipa Morais dos; Gonçalves, Vera Mónica Miranda; Baltazar, Fátima; Valença, Isabel; Ferreira, Ana Margarida; Aguiar, Cristina AlmeidaPortuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro ; Propolis is a resin collected by bees from plant buds and exudates, which is further processed through the activity of bee enzymes. Propolis has been shown to possess many biological and pharmacological properties, such as antimicrobial, antioxidant, immunostimulant and antitumor activities. Due to this bioactivity profile...
The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrup...
Granja, Sara Costa; Santos, Filipa Morais; Gonçalves, Vera M.; Ferreira, Manuel Viana; Nogueira, Rosete; Silva, Cristina Nogueira; Pinto, Jorge CorreiaBACKGROUND/AIMS: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids have an important role in cell metabolism and their rapid transport across the plasma membrane is crucial for the maintenance of intracellular pH homeostasis. This...
A hospital based cohort study of colorectal cancer cases treated at Braga Hospi...
Martins, Sandra; Reis, R. M.; Baltazar, Fátima; Longatto Filho, AdhemarBackground: Colorectal cancer (CRC) is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nonetheless, despite being a frequent cancer on which many epidemiological international studies have already been written, Portuguese epidemiological data are scarce and in particular there are very few specific data for Minho Region, which is traditionally recognized as a high inci...
Assessing the impact of a school intervention to promote students' knowledge an...
Pinheiro, Céline; Baltazar, FátimaThe clinical efficacy of antibiotics depends on their correct use. Widespread ignorance and inappropriate attitudes to antibiotic use have been identified among consumers. In order to improve the knowledge of middle-school students on antibiotics and their correct use, 82 ninth-grade students were enrolled in a teaching activity. The teaching activity consisted of a slide show presentation followed by discussio...
Cancer cell bioenergetics and pH regulation influence breast cancer cell resist...
Valente, Diana Tavares; Baltazar, Fátima; Moreira, Roxana; Queirós, OdíliaThe multidrug resistance (MDR) phenotype, frequently observed during cancer treatment, is often associated with drug efflux pump activity. However, many other factors are also known to be involved. Cancer cells often rely on aerobic glycolysis for energy production; this is known as the "Warburg effect" and is used as a survival mechanism. Associated to this event, a reverse pH gradient across the cell membrane...
CD147 immunohistochemistry discriminates between reactive mesothelial cells and...
Pinheiro, Céline; Longatto Filho, Adhemar; Ramos, Tony R.; Pereira, Helena; Bedrossian, Carlos; Michael, Claire; Schmitt, Fernando C.; Baltazar, FátimaMalignant mesothelioma (MM) is a rare form of cancer. Its histopathological diagnosis is very difficult, as it exhibits a number of different appearances that can be misinterpreted as metastatic invasion or atypical hyperplasia. Thus, there is an urgent need to identify adequate markers to distinguish between benign and malignantcells, allowing the implementation of appropriate therapies and, possibly, specifi...
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