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Role of endoglin and VEGF family expression in colorectal cancer prognosis and ...
Martins, SF; Reis, RM; Rodrigues, AM; Baltazar, F; Filho, ALColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognize...
Role of endoglin and VEGF family expression in colorectal cancer prognosis and...
Martins, SF; Reis, RM; Mesquita-Rodrigues, A; Baltazar, F; Filho, ALColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognize...
Role of endoglin and VEGF family expression in colorectal cancer prognosis and...
Martins, SF; Reis, RM; Mesquita-Rodrigues, A; Baltazar, F; Filho, ALColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognize...
Role of endoglin and VEGF family expression in colorectal cancer prognosis and ...
Martins, SF; Reis, RM; Rodrigues, AM; Baltazar, F; Filho, ALColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognize...
Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and the...
Pinheiro, C??line; Reis, R. M.; Ricardo, Sara; Longatto Filho, Adhemar; Schmitt, Fernando C.; Baltazar, F??timaExpression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. ; Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value of MCT expression in cancer is still poorly understood. In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as C...
Portuguese students' knowledge of antibiotics : a cross-sectional study of seco...
Azevedo, Maria Manuel; Pinheiro, C??line; Yaphe, John; Baltazar, F??timaBACKGROUND: Recent surveys show that the knowledge of the general public about the correct use of antibiotics is limited. This contributes to the problem of inappropriate antibiotic use, leading to a progressive loss of bacterial sensitivity to these drugs and the spreading of resistant strains of bacteria. METHODS: In this cross-sectional study, a questionnaire about antibiotic use was given to a sample of stu...
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous...
Longatto Filho, Adhemar; Pinheiro, C??line; Martinho, Olga Catarina Lopes; Moreira, Marise A. R.; Ribeiro, Luiz F. J.; Queiroz, Geraldo S.Art. No. 212 ; BACKGROUND: Adenosquamous carcinoma of the uterine cervix is an infrequent but aggressive subtype of cervical cancer. A better understanding of its biological behaviour is warranted to define more accurate prognosis and therapeutic targets. Currently, the blockage of receptor tyrosine kinase (RTKs) activity is an efficient therapeutic strategy for many different cancers. The objective of this st...
Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carc...
Pinheiro, Celine; Baltazar, F??tima; Longatto Filho, Adhemar; Pereira, S??nia Maria Miranda; Etlinger, Daniela; Moreira, Marise A. R.; Jub??, L. F.Due to the highly glycolytic metabolism of solid tumours, there is an increased acid production, however, cells are able to maintain physiological pH through plasma membrane efflux of the accumulating protons. Acid efflux through MCTs (monocarboxylate transporters) constitutes one of the most important mechanisms involved in tumour intracellular pH maintenance. Still, the molecular mechanisms underlying the reg...
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal ...
Pinheiro, C; Longatto-Filho, A; Scapulatempo, C; Mesquita-Rodrigues, A; Alves, VA; Schmitt, F; Baltazar, FTumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the exp...
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal ...
Pinheiro, C; Longatto-Filho, A; Scapulatempo, C; Mesquita-Rodrigues, A; Alves, VA; Schmitt, F; Baltazar, FTumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the exp...
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