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Carcinoma Gástrico e Gastrite Crónica : Regulação Epigenética por Metilação dos...
Silva, Maria; Azenha, Diana; Pereira, César; Almeida, Anabela; Balseiro, Sandra; Sampaio, Ana Maria; Santos, Paulo; Carvalho, LinaAs alterações genéticas e epigenéticas estão a ser estudadas como causas de progressão e desenvolvimento do carcinoma gástrico (CG). A metilação do DNA é uma alteração epigenética que provoca o silenciamento de genes supressores e activação de protooncogenes, facilitando a carcinogénese. Os vários tipos histológicos de carcinoma gástrico têm percursos genéticos diferentes, sendo que o conhecimento das bases mol...
Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadhe...
Silva, Maria; Azenha, Diana; Pereira, César; Almeida, Anabela; Balseiro, Sandra; Sampaio, Ana Maria; Santos, Paulo; Carvalho, LinaThe genetic and epigenetic alterations are being studied as one of the causes of gastric cancer (GC) progression and development. DNA methylation is an epigenetic alteration which leads to suppressor gene silencing and proto-oncogene activation, playing an important role in carcinogenesis. The histological types of gastric carcinoma have different genetic paths and the knowledge of the molecular bases of tumora...
Why are human newborns so fat? Relationship between fatness and brain size at b...
Correia, Hamilton R.; Balseiro, Sandra C.; Correia, Elisabete R.; Mota, Paulo G.; Areia, Manuel L. DeThe plumpness of the human newborn has long been recognized as a trait in need of explanation among researchers. Using a linear regression analysis, we find that head circumference is significantly and positively associated with BMI at birth, after gestational age and birthlength were controlled for, in a sample of 1,069 healthy liveborn routinely delivered at the University Hospital of Coimbra (partial correla...
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