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Rapeseed oil‑rich diet alters hepatic mitochondrial membrane lipid composition ...
Monteiro, João P.; Pereira, Cláudia V.; Silva, Ana M.; Maciel, Elisabete; Baldeiras, Inês; Peixoto, Francisco; Domingues, Maria R.; Jurado, Amália S.Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats were fed for 11, 22 and 33 days with a rapeseed oil-based diet and mitochondrial bioenergetics, a...
Oxidative stress adaptation in aggressive prostate cancer may be counteracted b...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
Bilateral Hyperintensity of the Pulvinar and Dorsomedial Nucleus of the Thalamu...
Casimiro, Carlos; Martins, Joana; Parreira, Tiago; Baldeiras, Inês; Ribeiro, Helena; Batista, Sónia; Machado, Egídio; Maduro, Ana; Rebelo, OlindaIntroduction: Creutzfedt-Jakob Disease (CJD) is a rapidly progressive neurodegenerative disease caused by prions. Early diagnosis and the determination of its form are epidemiologically important, with strong impact on public health. Bilateral pulvinar hyperintensity, either alone (pulvinar sign) or in association with the dorsomedial nucleus of the thalamus (double hockey stick sign) on T2, FLAIR and diffusion...
Regulation by glucose of oscillatory electrical activity and 5-HT/insulin relea...
Rosário, Luís M.; Barbosa, Rui M.; Antunes, Célia M.; Baldeiras, Inês E.; Silva, Amélia M.; Tomé, Ângelo R.; Santos, Rosa M.The glucose sensitivity of bursting electrical activity and pulsatile insulin release from pancreatic islets was determined in absence of functional KATP channels. Membrane potential, [Ca2+]i and 5-HT/insulin release were measured by intracellular recording, fura-2 fluorescence and 5-HT amperometry, respectively. Single mouse islets, bathed in tolbutamide or glibenclamide and high extracellular Ca2+ (Ca2+o), di...
Regulation by glucose of oscillatory electrical activity and 5-HT/insulin relea...
Antunes, Célia M.; Rosário, Luís M.; Barbosa, Rui M.; Silva, Amélia S.; Baldeiras, Inês E.; Tomé, Ângelo R.; Santos, Rosa M.The glucose sensitivity of bursting electrical activity and pulsatile insulin release from pancreatic islets was determined in absence of functional KATP channels. Membrane potential, [Ca2+]i and 5- HT/insulin release were measured by intracellular recording, fura-2 fluorescence and 5-HT amperometry, respectively. Single mouse islets, bathed in tolbutamide or glibenclamide and high extracellular Ca2+ (Ca2+o), d...
Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Pr...
Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Pascoal, Rui; Rabaça, Carlos; Valido, Frederico; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana BelaCigarette smoke is an oxidant, creating free radicals that are involved in carcinogenesis namely in Prostate Cancer (PC). However, a correlation between cigarette smoking and PC progression remains unclear. This study was directed to evaluate the correlation between cigarette smoking, Oxidative Stress (OS) and PC development and progression. The Total Antioxidant Status (TAS), Glutathione (GSH) and Malondialdeh...
Protein kinase C isoform specificity of cholinergic potentiation of glucose-ind...
Baldeiras, Inês E.; Santos, Rosa M.; Rosário, Luís M.Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol (Cch, 50 \u03bcM) enhanced PIR ~ 3-fold while reducing the underlying [Ca2+]i oscillations (duration and amplitude) by ~ 40-5...
Involvement of protein kinase C in cholinergic potentiation of glucose-induced ...
Baldeiras, Inês E.; Barbosa, Rui M.; Santos, Rosa M.; Rosário, Luís M.http://www.sciencedirect.com/science/article/B6T5Y-49PK0KM-M0/1/4edf2ccfe81c25b6f0ac732004095cd1
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