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Oxidative Stress Adaptation in Aggressive Prostate Cancer May Be Counteracted b...
Freitas, M; Baldeiras, I; Proença, T; Alves, V; Mota-Pinto, A; Sarmento-Ribeiro, AOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HP...
Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...
Almeida, A. M.; Falcão, A. C.; Sales, F.; Baldeiras, I.; Rocha, M. J.; Caramona, M. M.Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...
Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...
Almeida, A. M.; Falcão, Amílcar; Sales, F.; Baldeiras, I.; Rocha, M. J.; Caramona, M. M.Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...
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