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Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces erlotinib-Induced s...
Gregory, Marslin; Sheeba, Caroline J.; Kalaichelvan, V. K.; Manavalan, R.; Reddy, Neelakanta; Gregory, FranklinErlotinib-HCl is a quinazoline derivative used as a drug in the therapy of non-small-cell lung cancer. The present study was conducted to compare the subacute toxicity induced by Erlotinib-HCl delivered to rats as nanoparticles and as free drug. Wistar rats were orally administered with a daily dosage of 200 mg kg−1 Erlotinib-HCl either as free drug or as Poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulated na...
Anti-ulcer (ulcer-preventive) activity of ficus arnottiana miq. (moraceae) leaf...
Gregory, Marslin; Vithalrao, K. P.; Gregory, Franklin; Kalaichelvan, V. K.Problem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powder...
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