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Brain-derived neurotrophic factor regulates the expression and synaptic deliver...
Caldeira, Margarida V.; Melo, Carlos V.; Pereira, Daniela B.; Carvalho, Ricardo; Correia, Susana S.; Backos, Donald S.; Carvalho, Ana LuísaBrain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity in the hippocampus, but the mechanisms involved are not fully understood. The neurotrophin couples synaptic activation to changes in gene expression underlying long term potentiation and short term plasticity. Here we show that BDNF acutely up-regulates GluR1, GluR2, and GluR3 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propi...
Data: 2007
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Origem: Estudo Geral - Universidade de Coimbra
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