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Host- and microbe-related risk factors for and pathophysiology of fatal Rickett...
Sousa, R; França, A; Nóbrega, SD; Belo, A; Amaro, M; Abreu, T; Poças, J; Proença, P; Vaz, J; Torgal, J; Bacellar, F; Ismail, N; Walker, DBACKGROUND: The pathophysiologic mechanisms that determine the severity of Mediterranean spotted fever (MSF) and the host-related and microbe-related risk factors for a fatal outcome are incompletely understood. METHODS: This prospective study used univariate and multivariate analyses to determine the risk factors for a fatal outcome for 140 patients with Rickettsia conorii infection admitted to 13 Portuguese h...
Intralesional expression of mRNA of interferon- gamma, tumor necrosis factor- a...
Sousa, R; Ismail, N; Nóbrega, SD; França, A; Amaro, M; Anes, M; Poças, J; Coelho, R; Torgal, J; Bacellar, F; Walker, DBACKGROUND: The mechanisms of immunity to Rickettsia conorii that have been elucidated in mouse models have not been evaluated in human tissues. METHODS: In this study, quantitative real-time polymerase chain reaction was used to determine the levels of expression of inflammatory and immune mediators in skin-biopsy samples collected from 23 untreated patients with Mediterranean spotted fever (MSF). RESULTS: In ...
Bacillary Angiomatosis by Bartonella Quintana in an HIV-Infected Patient
Santos, R; Cardoso, O; Rodrigues, P; Cardoso, J; Machado, J; Afonso, A; Bacellar, F; Marston, E; Proença, RBacillary angiomatosis and bacillary peliosis are opportunistic infections caused by Bartonella henselae and Bartonella quintana, which occur in patients with late-stage infection. We report a case of bacillary angiomatosis in an HIV-infected patient with skin, bone, and probably liver involvement, The identification of the agent (B quintana ) was done by polymerase chain reaction in the skin specimen. The pati...
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