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Enxertos e substitutos ósseos em cirurgia ortopédica reconstrutiva nos animais ...
Dias, Isabel R.; Sousa, Cristina Maria Peixoto de; Carvalho, Pedro Miguel Pires de; Lempeck, Marthin Raboch; Viegas, Carlos A.; Azevedo, Jorge T.We present here an overview of the scientific literature concerning the clinical application of autografts and allografts of the skeletal tissues and of the natural and synthetic bone graft substitutes available in small animal orthopedic surgery for resolution of congenital, traumatic and tumoral etiology situations or for reconstructive artroplastic surgeries. This article focuses the terminology, definitions...
Tissue engineered constructs based on SPCL scaffolds cultured with goat marrow ...
Rodrigues, Márcia T.; Gomes, Manuela E.; Viegas, Carlos A.; Azevedo, Jorge T.; Dias, Isabel R.; Guzon, Fernando M.; Reis, R. L.This study aims to assess the in vivo performance of cell–scaffold constructs composed of goat marrow stromal cells (GBMCs) and SPCL (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. GBMCs from iliac crests were seeded onto SPCL scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. After 1 and 7 days, the constructs wer...
Assessment of bone formation markers under controlled environmental conditions ...
Dias, Isabel R.; Viegas, Carlos A.; Azevedo, Jorge T.; Costa, E. M.; Lourenço, P.; Rodrigues, A.; Cabrita, A. S.Eighteen healthy skeletally mature (3 years old) ewes, with an average weight of 45 kg, of the Portuguese Churra da Terra Quente breed were used to evaluate the normal values of total and bone-specific isoform of alkaline phosphatase serum activities (ALP and BALP, respectively) and serum osteocalcin (OC) and their correlation with the serum minerals – calcium (Ca), phosphorus (P), magnesium (Mg) and ionized ca...
Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engin...
Oliveira, Joaquim M.; Rodrigues, Márcia T.; Silva, S. S.; Malafaya, P. B.; Gomes, Manuela E.; Viegas, Carlos A.; Azevedo, Jorge T.; Dias, Isabel R.Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo of either bone and cartilage tissue, or both, as in the case of osteochondral defects. The later...
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