ResumoAs doenças pulmonares intersticiais (DPI) crónicas caracterizam-se por persistência ou recorrência de dispneia e/ou tosse, de desenvolvimento insidioso e duração superior a um mês, pela presença de infiltrados pulmonares bilaterais e por alterações das trocas gasosas. A prevalência na idade pediátrica é muito baixa e o diagnóstico etiológico e o tratamento são, em regra, difíceis. Em 1995, Katzenstein e c...
The Metabolic Syndrome increases the risk for atherosclerotic cardiovascular disease and type 2 Diabetes Mellitus. Increased fructose consumption and/or mineral deficiency have been associated with Metabolic Syndrome development. This study aimed to investigate the effects of 8 weeks consumption of a hypersaline sodium-rich naturally sparkling mineral water on 10% fructose-fed Sprague-Dawley rats (Metabolic Syn...
No primeiro ano da licenciatura em Ciências da Nutrição, na Faculdade de Ciências da Nutrição e Alimentação, da Universidade do Porto, existem duas Unidades Curriculares que introduzem a Bioquímica aos estudantes [Química Orgânica e Bioquímica I (no 1º e 2º semestres, respetivamente)] e cujos programas e modalidades pedagógicas estão inter-relacionados, confrontando o estudante, progressivamente ao longo do ano...
Alkaline phosphatase (ALP) is important in calcification and its expression seems to be associated with the inflammatory process. We investigated the in vitro acute effects of compounds used for the prevention or treatment of cardiovascular diseases on total ALP activity from male Wistar rat heart homogenate. ALP activity was determined by quantifying, at 410 nm, the p-nitrophenol released from p-nitrophenylpho...
Our objective was to characterize the modulation of the activity of Saccharomyces cerevisiae alkaline phosphatases (ALPs) by classic inhibitors of ALP activity, cholesterol and steroid hormones, in order to identify catalytic similarities between yeast and mammalian ALPs. S. cerevisiae expresses two ALPs, coded for by the PHO8 and PHO13 genes. The product of the PHO8 gene is repressible by Pi in the medium. ALP...
Background: The clinical spectrum of congenital cystic adenomatoid malformation of the lung to the neonatal intensive care units of five tertiary medical centres in the north of Portugal between 1996 and 2005. Results: Fifteen neonates with CCAML were identified, 9F/6M, birth weight 3100 g (645-3975), gestational age 38 weeks (24-40). The incidence of CCAML was 1: 9300 births. There were 11 (73%) cases of cysti...
In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed.To characterize serum levels of alkaline phosphatase activity in humans according to age and gender.Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years.In men (n=87) total serum alkaline phosphatase markedly increased from the 5th to the 6...
Optimal experimental designs for maximum precision in the estimation of diffusivities (D) and mass transfer coefficients (Kc) for solute transport from/to a solid immersed in a fluid were determined. Diffusion in the solid was considered to take place according to Fick's second law. It was found that the optimal design was dependent on the Biot number. In the range of Biot numbers tested (0.1±200), the first sa...
The use of Information and Communication Technologies for the divulgation of the geological heritage must be faced as a priority. Due to their characteristics, the possibility of presenting geological features is greatly enhanced using multimedia materials distributed by Internet or in CD-ROM's. In this work we present the project under development, centered on the production of electronic materials regarding t...
Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: maternal age, parity, gestational age, the mode of delivery, the fetal weight, the maternal and fetal...
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