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Dynamic culture of osteogenic cells in biomimetically coated poly(caprolactone)...
Araújo, J. V.; Reis, C. Cunha; Rada, Tommaso; Silva, Marta Alves da; Gomes, Manuela E.; Yang, Y.; Ashammakhi, N.; Reis, R. L.; El-Haj, Alicia J.In our previous work, biomimetic calcium phosphate-coated poly(caprolactone) nanofibre meshes (BCP-NMs) were demonstrated to be more effective for supporting cell attachment and proliferation under static conditions, when compared with poly(caprolactone) nanofibre meshes (PCL-NMs). In many applications, in vitro cultivation of constructs using bioreactors that support efficient nutrition of cells has appeared a...
Development of a bioactive glass fiber reinforced starch-polycaprolactone compo...
Jukola, H.; Nikkola, L.; Gomes, Manuela E.; Chiellini, F.; Tukiainen, M.; Kellomaki, M.; Chiellini, E.; Reis, R. L.; Ashammakhi, N.For bone regeneration and repair, combinations of different materials are often needed. Biodegradable polymers are often combined with osteoconductive materials, such as bioactive glass (BaG), which can also improve the mechanical properties of the composite. The aim of this work was to develop and characterize BaG fiber reinforced starch–poly-ecaprolactone (SPCL) composite. Sheets of SPCL (30/70 wt %) were pro...
Biodegradable nanomats produced by electrospinning : expanding multifunctionali...
Ashammakhi, N.; Ndreu, A.; Piras, A. M.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Gomes, Manuela E.; Neves, N. M.; Chiellini, E.With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the techniqu...
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