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Assessing the involvement of Dis3L1 in mammalian quality control pathways
Reis, Filipa Pereira; Teixeira, Alexandre; Cruz, David; Morgado, Ana; Arraiano, Cecília Maria; Romão, LuísaThe exosome is an evolutionarily conserved protein complex that is involved in all aspects of RNA metabolism, namely, RNA decay, processing and quality control. The only catalytic subunit of the core exosome is a 3´end exoribonuclease from the RNase II family of enzymes. In humans, two different homologues of this protein were identified, Dis3 and Dis3L1. While Dis3 mainly localizes in the nucleoplasm and has e...
Discovery and initial characterization of members of the new YaaH family of mic...
Pessoa, Joana Sá; Viegas, Sandra; Rocha, Gabriel Azevedo Carreira Talaia da; Diallinas, George; Paiva, Sandra; Arraiano, Cecilia; Casal, MargaridaThe emergence of probiotics and prebiotics has revived the importance of short-chain fatty acids (SCFAs) associated to colonic and systemic health improvement. Although biosynthesis and degradation of SCFAs and other short-chain carboxylic acids, such as lactate, pyruvate or citrate are well understood, the transport of these acids is still a matter of discussion. The presence of SCFAs transporters in cellular ...
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