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Differential impact of chronic stress along the hippocampal dorsal???ventral axis
Pinto, V??tor; Costa, Jo??o Carlos Cardoso; Morgado, Pedro; Mota, Cristina de F??tima Sousa da; Miranda, A.; Bravo, Ana Francisca Rodrigues VazPublished online 06 February 2014 ; Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chronic unpredictable stress (CUS) paradigm on the dorsal-ven...
A web platform and a decision model for computer-interpretable guidelines
Oliveira, Tiago Gil; Novais, Paulo; Neves, JoséSituations of medical error and defensive medicine are com- mon in healthcare environments and have repercussions in the quality of care under o er. The occurrence of adverse events and the increase of healthcare expenses are some of the consequences of medical malpractice. Indeed, these situations may be prevented by encouraging the compli- ance with Clinical Guidelines (CGs). However, the current format of CG...
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
Chan, Robin B.; Oliveira, Tiago Gil; Cortes, Etty P.; Honig, Lawrence S.; Duff, Karen E.; Small, Scott A.; Wenk, Markus R.; Shui, GuanghouLipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based approach was employed to determine the lipidome of brain tissues affected by AD. Specifically, we used liquid chromatography-mass spectrometry to profile extracts from the prefrontal cortex, entorhinal cortex, and cerebellum of late-onset AD (LO...
Interplay between depressive-like behavior and the immune system in an animal m...
Roque, Susana; Oliveira, Tiago Gil; Nóbrega, Cláudia; Silva, Palmira Barreira; Alves, Cláudio Nunes; Sousa, Nuno; Palha, Joana AlmeidaGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression,...
The role of phospholipase D2 in Alzheimer's disease
Oliveira, Tiago GilTese de doutoramento em Ciências da Saúde (ramo do conhecimento em Medicina) ; Growing evidence implicates aberrant lipid signaling in Alzheimer‟s disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-peptide (Aβ) through a dysregulation of arachidonic acid and phosphatidylinositol-4,5-bisphosphate metabolism, respectively, the role of phospholipase D (PLD) ha...
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfu...
Oliveira, Tiago Gil; Chan, Robin B.; Tian, Huasong; Laredo, Mikael; Shui, Guanghou; Staniszewski, Agnieszka; Zhang, Hong; Wang, Lili; Kim, Tae-WanGrowing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid ??-peptide (A??) through a dysregulation of arachidonic acid and phosphatidylinositol-4,5-bisphosphate metabolism, respectively, the role of phospholipase D (PLD) has so far remained elusive. PLD produces phosphatidic acid (PA), a bioactive li...
How useful is the assessment of lymphatic vascular density in oral carcinoma pr...
Longatto Filho, Adhemar; Oliveira, Tiago Gil; Pinheiro, Céline; Carvalho, Marcos Brasilino; Curioni, Otávio Alberto; Mercante, Ana Maria da CunhaBackground: Lymphatic vessels are major routes for metastasis in head and neck squamous cell carcinoma (HNSCC), but lymphatic endothelial cells (LECs) are difficult to recognize in tumor histological sections. D2-40 stains podoplanin, a molecule expressed in LECs, however, the potential prognostic usefulness of this molecule is not completely understood in HNSCC. We aimed to investigate the value of assessing p...
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