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Inhibition of Mitochondrial Complex III Blocks Neuronal Differentiation and Mai...
Sandro, L. Pereira; Grãos, Mário; Rodrigues, Ana Sofia; Anjo, Sandra I.; Carvalho, Rui A.; Oliveira, Paulo J.; Arenas, Ernest; Ramalho-Santos, JoãoThe mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we sought to understand the effect of mitochondrial complex III inhibition during neuronal differentiation of mouse embryonic stem cells. When exposed to antimycin A, a specific complex III inhibitor, embryonic stem cells failed to differentiate into dopaminer...
Data: 2013
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Origem: Estudo Geral - Universidade de Coimbra
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