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Antioxidant effect of flavonoids after ascorbate/Fe2+-induced oxidative stress ...
Areias, Filipe Miguel; Rego, A. Cristina; Oliveira, Catarina R.; Seabra, Rosa MariaIn this study, we investigated the structure-activity relationship of four flavonoids, i.e. eriodictyol, luteolin, quercetin, and taxifolin, in cultured retinal cells after ascorbate/Fe2+-induced oxidative stress. The relative order of antioxidant efficacy, determined by the thiobarbituric acid method, was the following: eriodictyol > quercetin > luteolin > taxifolin. Upon preincubation, the flavonoids were als...
Effect of Glucose Deprivation and Acute Glutamate Exposure in Cultured Retinal ...
Rego, Ana Cristina; Areias, Filipe Miguel; Santos, Maria Sancha; Oliveira, Catarina R.The relationship between bioenergetics and the glutamate system was analyzed in a neuronal model of retinal cells in culture, submitted to glucose deprivation and exposed to glutamate for 2 h, and compared with exposure to glutamate in the presence of glucose. Under glucose deprivation, a reduction (about 1.1-fold) in the energy charge of the cells occurred, probably as a result of a decrement (by about 75%) in...
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